Significance of HPV genotype detection in diagnosis of cervical lesion

doi:10.16150/j.1671-2870.2016.05.017

Abstract

Abstract: Objective: To investigate the infection of different genotypes of papillomavirus (HPV) and the relationship between high-risk HPV genotype and cervical lesion in females. Methods: HPV genotype detection was performed in 1 669 subjects. Colposcopy was conducted in positive cases after informed consent was obtained and biopsy was performed in suspected cases under colposcopy. Results: Five hundred and sixty-seven cases of the 1 669 subjects were HPV positive, with a positive rate of 33.97% (567/1 669). The five leading frequencies of HPV genotype were HPV-16 (9.05%), HPV-52 (7.85%), HPV-58 (6.29%), HPV-CP8304 (5.81%), HPV-53 (3.71%). Women ≤30 were at the peak of HPV infection when compared with other ages. Four hundred and fifty-four cases of 567 HPV positive subjects were infected with high-risk HPV genotype. The five leading frequencies of high-risk HPV infection with high grade squamous intraepithelial lesion (HSIL) in biopsy were HPV-16 (58 cases), HPV-52 (26 cases), HPV-58 (25 cases), HPV-18 (25 cases), HPV-31 (6 cases). Conclusions: The peak age for HPV infection is getting younger, and HPV genotype detection has significant value in the diagnosis of cervical lesion, especially HPV-16, HPV-52, HPV-58, HPV-18, HPV-31, they are closely associated with cervical cancer.

Key words: Human papillomavirus, Genotype, Cervical lesions

CLC Number:

R737.33

GU Zhengrong, WU Hong, WANG Ling. Significance of HPV genotype detection in diagnosis of cervical lesion[J]. Journal of Diagnostics Concepts & Practice, 2016, 15(05): 517-520.

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