Journal of Diagnostics Concepts & Practice ›› 2024, Vol. 23 ›› Issue (04): 430-438.doi: 10.16150/j.1671-2870.2024.04.012
• Review article • Previous Articles Next Articles
ZHAO Lijuan1,2a, CHENG Tao2a, SHUI Xinjun2b, YUE Dongqi1, QIN Shaochen3, LIU Xiaoling4, WANG Jiali1(), FU Yi1(
)
Received:
2024-03-10
Accepted:
2024-06-13
Online:
2024-08-25
Published:
2024-08-25
Contact:
WANG Jiali, FU Yi
E-mail:302668818@qq.com;fuyiki@sina.com
CLC Number:
ZHAO Lijuan, CHENG Tao, SHUI Xinjun, YUE Dongqi, QIN Shaochen, LIU Xiaoling, WANG Jiali, FU Yi. Advances in study on risk factors related to cerebral microbleeds and on treatment decision-making when cerebral microbleeds merging related diseases[J]. Journal of Diagnostics Concepts & Practice, 2024, 23(04): 430-438.
Table 1
SNPs associated with cerebral microbleeds, presence(P values<1×10-5)
CHR | SNP | Minor allele | MAF | Closest gene | Gene functions | SNP location | OR | P |
---|---|---|---|---|---|---|---|---|
1 | rsl144266 | C | 0.34 | LINC01362 | Unknown | Intron | 0.45 | 1.01×10-6 |
4 | rs1850549 | T | 0.17 | LOC105374510 | Unknown | Intron | 2.56 | 1.84×10-6 |
1 | rs10493734 | T | 0.33 | LINC01361 | Unknown | Intron | 0.46 | 2.43×10-6 |
1 | rsl144267 | T | 0.34 | LINC01362 | Unknown | Intron | 0.47 | 2.49×10-6 |
1 | rs7411897 | A | 0.34 | LINC01362 | Unknown | Intron | 0.47 | 2.83×10-6 |
12 | rs6581525 | G | 0.38 | SRGAP1 | Regulating neuronal migration | Intron | 2.05 | 3.39×10-6 |
1 | rsl1163625 | G | 0.34 | LINC01362 | Unknown | Intron | 0.47 | 3.69×10⁶ |
1 | rs12132310 | A | 0.28 | LOC107985396 | Unknown | 438K | 0.46 | 3.92×10-6 |
1 | rs10782802 | G | 0.34 | LINC01361 | Unknown | Intron | ||
2 | rs1368908 | A | 0.24 | CTNNA2 | Lossof CTNNA2 lead to defect in neurite stability and migration | Intron | 2.21 | 5.18×10-6 |
1 | rs1348045 | A | 0.34 | LINC01362 | Unknown | Intron | ||
7 | rs10263645 | C | 0.21 | AMPH | Encoding amphiphysin which is required for dendrite maturation | Intron | 0.41 | 5.65×10-6 |
1 | rsl1163602 | G | 0.34 | LINC01362 | Unknown | 461K | 0.48 | 5.66×10-6 |
4 | rs66690887 | A | 0.28 | LOC105374510 | Unknown | Intron | 2.05 | 5.85×10-6 |
4 | rs67159217 | T | 0.28 | LOC105374510 | Unknown | Intron | 2.05 | 5.85×10-6 |
1 | rs12140057 | A | 0.28 | LOC107985396 | Unknown | 456K | 0.47 | 6.31×10-6 |
1 | rsl1163585 | T | 0.28 | LOC107985396 | Unknown | 443K | 0.47 | 6.31×10-6 |
4 | rs10027565 | A | 0.39 | LOC105374510 | Unknown | Intron | 1.97 | 7.32×10-6 |
3 | rs12497385 | T | 0.47 | LOC105374287 | Unknown | Intron | 0.51 | 8.46×10-6 |
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