Table 1

Clinical data of patients with HIV combined with CMV infection

Figure 1

Pathomorphologic and immunohistochemical features of CMV infection in the gastric mucosa and ileocecal part A: Giant eosinophilic inclusion bodies with perinuclear halos (green arrows) were seen in multiple intestinal mucosal epithelial nuclei in the ileocecal region. (HE, ×400); B: Intestinal mucosal intraepithelial inclusion bodies with strong positive CMV protein expression.(IHC, ×400); C: Gastric mucosal ulcer formation, massive acute and chronic inflammatory cell infiltration in the interstitium, enlarged mucosal epithelial cytosol, slightly basophilic cytoplasm, and eosinophilic intranuclear inclusion bodies (green arrows). (HE, ×400); D: Inflammatory necrotic area of gastric mucosal epithelium with positive expression of CMV protein. (IHC, ×400).

Figure 2

Pathomorphologic, immunohistochemical and special staining features of CMV combined with aspergillus infection in lung puncture tissue A: Lung puncture tissue (HE, ×40); B: Localized inflammatory cell infiltration, fibrous tissue hyperplasia, and two intranuclear inclusions in macrophages (green arrows) of lung tissue (HE, ×400); C: Immunohistochemistry shown CMV inclusion bodies is brown (IHC, ×400); D: The pseudohyphae and fungal spores with segregation and branching at acute angles under local magnification, its morphology consistent with aspergillus (red arrows) (PAS, × 400); E: The fungus is blackish brown (blue arrow), (PAS and Hexamethylamine silver staining, × 400).

Figure 3

Pathomorphologic and immunohistochemical features of CMV infection in submandibular lymph nodes and esophageal mucosa A: Viral inclusion bodies are seen in the nuclei of multiple macrophages in submandibular lymph nodes (green arrow) (HE, × 400); B:Immunohistochemistry shown CMV positivity in figure A (IHC, ×400); C: AIDS esophageal mucosal biopsy with infiltration of inflammatory cells under squamous epithelium, and numerous viral inclusion bodies seen in the nuclei of multiple cells (green arrows) (HE, × 400); D: Immunohistochemistry shown CMV positive expression in figure C (IHC, ×400).

Figure 4

Histopathologic and immunohistochemical characteristics of CMV infection in transverse colon mucosal Inflammatory cell infiltration and an eosinophilic inclusion body in the nucleus are seen (green arrow) in the mucosal interstitium of the transverse colon.(HE, ×400); B: Foci of intestinal mucosal inflammatory necrosis, small focal eosinophilic changes were seen (yellow arrows) (HE, ×400); C, D: Showing Figure A, B CMV immunohistochemistry the amount of intranuclear inclusion bodies increased significantly and became more clearly visible (IHC, ×400).

Figure 5

Pathomorphology and special staining features of colonic mucosa combined with Talaromyces marneffei and Mycobacterium tuberculosis infections (×1 000) A: Fungal spores were detected in foam cells and tissue interstitial space in the intestinal mucosa, see magnified picture in the upper right corner (HE, ×1 000); B: PAS stain shown that fungal spores are salami like with separation in the middle, its morphology is consistent with Talaromyces marneffei (PAS, × 1 000); C: Talaromyces marneffei is in dark brown color (PAS and Hexamethylamine silver staining, ×1 000); D: Intestinal mucosal antacid stai-ning shown mycobacteria in red color (Ziehl-Neelsen, ×1 000).