Effect of game-based EEG neurofeedback training on improvement of cognitive function

doi:10.16150/j.1671-2870.2022.01.009

Abstract

Abstract:

Objective: To observe the effect of game-based EEG neurofeedback system on improvement of cognitive function in the patients with cognitive impairment. Methods: Fifty-two patients with cognitive impairment, mainly memory decline, were included, and the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment Scale (MoCA) and Alzheimer′s Disease Assessment Scale-Cognitive section(ADAS-cog) were conducted in the patients to evaluate cognitive impairment. Five days later, each patient was given 30-min EEG neural feedback training, once a day for 10 consecutive days. The EEG was detected before and after training, and MMSE, MoCA and ADAS-cog scores were also evaluated after training. Results: The scores of MMSE, MoCA and ADAS-cog scales after training were all higher(26.06±2.95, 21.88±3.94, 12.15±5.15) than those before training (23.10±2.82, 18.63±4.10, 14.76±5.30) (P<0.05). Before training, the scores of memory on MMSE, MoCA and ADAS-cog scales were 1.55±0.77, 1.33±1.28, 4.35±1.11, respectively, while the above scores increased to 2.16±0.80, 2.29±1.34, 3.93±1.30(P<0.001) after training. The EEG after training showed that the complexity of EEG was improved than that before training, mainly in the left frontal lobe. Conclusions: The game-based EEG neurofeedback system training can significantly improve cognitive function and EEG complexity in the left prefrontal lobe.

Key words: EEG neurofeedback, Memory decline, Cognitive impairment

CLC Number:

R541.7

MA Shaochen, GUO Xin, WANG Mingwei, WANG Huijun, YU Qijun, SU Wenyue, WANG Hualong, MA Qinying. Effect of game-based EEG neurofeedback training on improvement of cognitive function[J]. Journal of Diagnostics Concepts & Practice, 2022, 21(01): 41-45.

Figures/Tables 3

References 21

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项目	认知障碍患者（n=49）
项目	平均数	中位数	最小值	最大值
年龄（岁）	68.53（6.76）	71.00（9.00）	51	80
身高（mm）	164.31（8.86）	165.00（14.00）	140	180
体重（kg）	68.74（11.00）	70.00（15.00）	47	100
受教育年限（年）	8.10（3.28）	9.00（4.00）	2	17

量表	认知领域	认知功能障碍患者（n=49）
量表	认知领域	训练前（$\bar{x}\pm s$）	训练后（$\bar{x}\pm s$）	t值	P值
MMSE	定向力	8.69±1.28	9.43±1.25	-4.335	<0.001
	即刻回忆	2.90±0.31	2.94±0.24	-1.000	0.322
	注意力和计算力	2.92±0.98	3.73±1.26	-6.157	<0.001
	回忆	1.55±0.77	2.16±0.80	-5.12	<0.001
	语言	7.04±1.27	7.80±1.08	-5.715	<0.001
	MMSE总分	23.10±2.82	26.06±2.95	-17.163	<0.001
MoCA	视空间与执行功能	3.43±1.02	3.65±1.01	-1.909	0.062
	命名	2.29±0.71	2.49±0.65	-2.478	0.017
	注意	4.24±1.41	5.02±1.22	-5.093	<0.001
	语言	1.43±0.76	1.86±0.74	-3.795	<0.001
	抽象	0.80±0.76	1.02±0.80	-2.529	0.015
	延迟回忆	1.33±1.28	2.29±1.34	-6.221	<0.001
	定向	5.12±1.01	5.55±0.87	-3.464	<0.001
	MoCA总分	18.63±4.10	21.88±3.94	-11.098	<0.001
ADAS-cog	单词回忆	4.35±1.11	3.93±1.30	3.891	<0.001
	命名	0.33±0.47	0.08±0.28	3.946	<0.001
	命令	1.29±0.71	1.37±0.83	-0.753	0.455
	结构性练习	0.53±0.50	0.35±0.52	2.438	0.019
	意向性练习	0.53±0.58	0.12±0.39	5.322	<0.001
	定向	0.94±0.94	0.47±0.868	3.892	<0.001
	单词辨认	2.33±1.675	1.59±1.338	5.183	<0.001
	回忆测验指令	1.12±0.949	1.04±0.87	1.000	0.322
	口语能力	0.63±0.76	0.61±0.70	0.573	0.569
	找词困难	0.51±0.79	0.53±0.77	-0.330	0.743
	语言理解力	0.94±0.78	0.90±0.71	0.531	0.598
	注意力	1.27±0.73	1.06±0.83	1.400	0.168
	ADAS-cog总分	14.76±5.30	12.15±5.15	16.056	<0.001

导联	认知功能障碍患者（n=49）
导联	第1天（$\bar{x}\pm s$）	第10天（$\bar{x}\pm s$）	秩和S	P值
FP1	0.09±0.02	0.13±0.02	-26.50	0.022 6
FP2	0.09±0.02	0.13±0.02	-183.50	0.067 4
F3	0.09±0.02	0.13±0.02	-144.50	0.152 6
F4	0.10±0.02	0.13±0.02	-92.50	0.362 9