Abstract: Objective: To explore the endoscopic detection rate and composition ratio of acid-related diseases in health check-up subjects for providing a clinical reference for the guiding of treatment strategy. Methods: From January 2015 to December 2016, a total of 12 293 health check-up subjects aged 30-79 years were enrolled. All the subjects underwent endoscopy as a health check-up program, and the subjects were divided into 5 age groups. Reflux esophagitis (RE) and peptic ulcer (PU) were confirmed by gastroscopy. Results: The detection rates of RE and PU were 8.8% (1 087 cases) and 8.0% (981 cases), respectively. For male subjects, the detection rates of RE and PU were 13.1% and 11.5%, respectively; in female subjects, the corresponding rates were 4.9% and 4.7%, respectively. The detection rates of RE and PU in male subjects were 9.2% and 10.5% in 30-39 age group, 12.4% and 10.7% in 40-49 age group, 12.9% and 11.4% in 50-59 age group, 15.0% and 13.5% in 60-69 age group, and 15.9% and 9.3% in 70-79 age group, respectively, while the corresponding detection rates in female subjects were 2.6% and 3.6%, 3.3% and 4.6%, 4.3% and 4.3%, 6.4% and 5.2%, and 9.6% and 6.1%, respectively. In male subjects, the detection rate of RE was significantly higher in the 40-49 age group than that in the 30-39 age group (12.4% vs. 9.2%, P<0.05), and was close to that in 50-59 age group (12.4% vs. 12.9%, P>0.05). Conclusions: The endoscopic detection rate of RE is higher than that of PU in the health check-up subjects. Male patients are the key population for prevention and treatment of acid-related diseases, especially in 40-49 age group.

Key words: Acid-related diseases, Reflux esophagitis, Peptic ulcer, Proton pump inhibitor, Endoscopy