Journal of Diagnostics Concepts & Practice ›› 2021, Vol. 20 ›› Issue (06): 567-572.doi: 10.16150/j.1671-2870.2021.06.010
• Original articles • Previous Articles Next Articles
MENG Juna, XU Xiaoshengb, LU Yiyia, FAN Zhenjiaa, CAI Ganga()
Received:
2021-02-18
Online:
2021-12-25
Published:
2021-12-25
Contact:
CAI Gang
E-mail:caigangsmmu@hotmail.com
CLC Number:
MENG Jun, XU Xiaosheng, LU Yiyi, FAN Zhenjia, CAI Gang. 2017-2020 survey of HPV infection subtypes in the cervical exfoliated cells in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2021, 20(06): 567-572.
HPV亚型 | 检出次数(次) | 检出率 |
---|---|---|
52型 | 1 950 | 3.31% |
58型 | 1 206 | 2.05% |
16型 | 1 129 | 1.92% |
53型 | 1 062 | 1.80% |
51型 | 729 | 1.24% |
56型 | 632 | 1.07% |
66型 | 563 | 0.96% |
68型 | 547 | 0.93% |
31型 | 513 | 0.87% |
33型 | 474 | 0.80% |
59型 | 463 | 0.79% |
39型 | 421 | 0.71% |
81型 | 385 | 0.65% |
18型 | 377 | 0.64% |
42型 | 339 | 0.58% |
44型 | 260 | 0.44% |
6型 | 244 | 0.41% |
43型 | 220 | 0.37% |
35型 | 197 | 0.33% |
82型 | 180 | 0.31% |
11型 | 158 | 0.27% |
45型 | 109 | 0.19% |
73型 | 103 | 0.17% |
26型 | 68 | 0.12% |
83型 | 58 | 0.10% |
亚型 | 数量(n) | 单重感染 | 多重感染 |
---|---|---|---|
52型 | 1 950 | 1 201(61.59%) | 749(38.41%) |
58型 | 1 206 | 742(61.53%) | 464(38.47%) |
31型 | 513 | 315(61.40%) | 198(38.60%) |
16型 | 1 129 | 689(61.03%) | 440(38.97%) |
53型 | 1 062 | 647(60.92%) | 415(39.08%) |
11型 | 158 | 94(59.49%) | 64(40.51%) |
68型 | 547 | 324(59.23%) | 223(40.77%) |
56型 | 632 | 366(57.91%) | 266(42.09%) |
33型 | 474 | 261(55.06%) | 213(44.94%) |
51型 | 729 | 398(54.60%) | 331(45.40%) |
81型 | 385 | 207(53.77%) | 178(46.23%) |
44型 | 260 | 137(52.69%) | 123(47.31%) |
66型 | 563 | 296(52.58%) | 267(47.42%) |
35型 | 197 | 100(50.76%) | 97(49.24%) |
45型 | 109 | 55(50.46%) | 54(49.54%) |
42型 | 339 | 171(50.44%) | 168(49.56%) |
18型 | 377 | 188(49.87%) | 189(50.13%) |
39型 | 421 | 204(48.46%) | 217(51.54%) |
59型 | 463 | 220(47.52%) | 243(52.48%) |
6型 | 244 | 111(45.49%) | 133(54.51%) |
82型 | 180 | 72(40.00%) | 108(60.00%) |
83型 | 58 | 23(39.66%) | 35(60.34%) |
43型 | 220 | 86(39.09%) | 134(60.91%) |
26型 | 68 | 26(38.24%) | 42(61.76%) |
73型 | 103 | 37(35.92%) | 66(64.08%) |
HPV基因型 | ≤20岁组 | 21~30岁组 | 31~40岁组 | 41~50岁组 | 51~60岁组 | ≥61岁组 |
---|---|---|---|---|---|---|
高危型 | ||||||
16型 | 17(9.34%) | 267(8.73%) | 334(9.42%) | 241(10.16%) | 141(7.89%) | 129(12.61%) |
18型 | 8(4.40%) | 102(3.33%) | 107(3.02%) | 77(3.25%) | 61(3.41%) | 22(2.15%) |
31型 | 2(1.10%) | 116(3.79%) | 163(4.60%) | 112(4.72%) | 77(4.31%) | 43(4.20%) |
33型 | 8(4.40%) | 122(3.99%) | 150(4.23%) | 92(3.88%) | 68(3.80%) | 34(3.32%) |
35型 | 1(0.55%) | 47(1.54%) | 65(1.83%) | 36(1.52%) | 37(2.07%) | 11(1.08%) |
39型 | 9(4.95%) | 124(4.05%) | 122(3.44%) | 86(3.63%) | 49(2.74%) | 31(3.03%) |
45型 | 1(0.55%) | 31(1.01%) | 30(0.85%) | 28(1.18%) | 14(0.78%) | 5(0.49%) |
51型 | 5(2.75%) | 217(7.09%) | 221(6.23%) | 136(5.73%) | 89(4.98%) | 61(5.96%) |
52型 | 22(12.09%) | 496(16.21%) | 588(16.59%) | 387(16.32%) | 288(16.11%) | 169(16.52%) |
53型 | 8(4.40%) | 220(7.19%) | 291(8.21%) | 238(10.03%) | 191(10.68%) | 115(11.24%) |
56型 | 11(6.04%) | 147(4.80%) | 175(4.94%) | 117(4.93%) | 106(5.93%) | 76(7.43%) |
58型 | 9(4.95%) | 282(9.22%) | 376(10.61%) | 239(10.08%) | 192(10.74%) | 108(10.56%) |
59型 | 10(5.49%) | 145(4.74%) | 127(3.58%) | 81(3.41%) | 72(4.03%) | 29(2.83%) |
66型 | 13(7.14%) | 151(4.93%) | 193(5.44%) | 89(3.75%) | 75(4.19%) | 42(4.11%) |
68型 | 7(3.85%) | 130(4.25%) | 177(4.99%) | 103(4.34%) | 95(5.31%) | 35(3.42%) |
81型 | 2(1.10%) | 73(2.39%) | 97(2.74%) | 96(4.05%) | 80(4.47%) | 37(3.62%) |
低危型 | ||||||
11型 | 18(9.89%) | 75(2.45%) | 32(0.90%) | 15(0.63%) | 12(0.67%) | 6(0.59%) |
42型 | 7(3.85%) | 87(2.84%) | 110(3.10%) | 62(2.61%) | 45(2.52%) | 28(2.74%) |
43型 | 9(4.95%) | 63(2.06%) | 65(1.83%) | 45(1.90%) | 26(1.45%) | 12(1.17%) |
44型 | 4(2.20%) | 58(1.90%) | 60(1.69%) | 70(2.95%) | 49(2.74%) | 19(1.86%) |
6型 | 11(6.04%) | 107(3.50%) | 62(1.75%) | 22(0.93%) | 21(1.17%) | 11(1.08%) |
合计 | 182(100%) | 3 060(100%) | 3 545(100%) | 2 372(100%) | 1 788(100%) | 1 023(100%) |
HPV基因型 | 株数(构成比) | 宫颈病变情况 | ||||||
---|---|---|---|---|---|---|---|---|
慢性子宫颈炎 | 宫颈息肉 | 宫颈上皮内瘤变 | CINⅠ级 | CINⅡ级 | CINⅢ级 | 宫颈恶性肿瘤 | ||
高危型 | ||||||||
16型 | 266(12.64%) | 174(10.16%) | 5(11.63%) | 11(17.46%) | 12(18.75%) | 1(16.67%) | 13(27.66%) | 50(29.59%) |
18型 | 85(4.04%) | 76(4.44%) | 0(0) | 0(0) | 3(4.69%) | 0(0) | 1(2.13%) | 5(2.96%) |
31型 | 86(4.09%) | 69(4.03%) | 3(6.98%) | 2(3.17%) | 3(4.69%) | 0(0) | 0(0) | 9(5.33%) |
33型 | 90(4.28%) | 77(4.50%) | 0(0) | 3(4.76%) | 3(4.69%) | 1(16.67%) | 3(6.38%) | 3(1.78%) |
35型 | 48(2.28%) | 35(2.04%) | 1(2.33%) | 1(1.59%) | 0(0) | 0(0) | 2(4.26%) | 9(5.33%) |
39型 | 80(3.8%) | 65(3.79%) | 2(4.65%) | 1(1.59%) | 2(3.13%) | 0(0) | 0(0) | 10(5.92%) |
45型 | 19(0.9%) | 13(0.76%) | 2(4.54%) | 2(3.17%) | 1(1.56%) | 0(0) | 0(0) | 1(0.59%) |
51型 | 144(6.84%) | 129(7.53%) | 2(4.65%) | 1(1.59%) | 5(7.81%) | 0(0) | 3(6.38%) | 4(2.37%) |
52型 | 344(16.34%) | 290(16.93%) | 4(9.30%) | 14(22.22%) | 8(12.5%) | 2(33.33%) | 7(14.89%) | 19(11.24%) |
53型 | 143(6.79%) | 116(6.77%) | 3(6.98%) | 4(6.35%) | 4(6.25%) | 1(16.67%) | 2(4.26%) | 13(7.69%) |
56型 | 99(4.7%) | 81(4.73%) | 4(0.93%) | 3(4.76%) | 2(3.13%) | 0(0) | 5(10.64%) | 4(2.37%) |
58型 | 228(10.83%) | 183(10.68%) | 5(11.63%) | 9(14.29%) | 8(12.5%) | 0(0) | 6(12.77%) | 17(10.06%) |
59型 | 87(4.13%) | 72(4.20%) | 1(2.33%) | 3(4.76%) | 4(6.25%) | 0(0) | 1(2.13%) | 6(3.55%) |
66型 | 119(5.65%) | 102(5.95%) | 2(4.65%) | 2(3.17%) | 3(4.69%) | 1(16.67%) | 4(8.52%) | 5(2.96%) |
68型 | 75(3.56%) | 64(3.74%) | 4(9.30%) | 2(3.17%) | 0(0) | 0(0) | 0(0) | 5(2.96%) |
81型 | 48(2.28%) | 38(2.22%) | 3(6.98%) | 2(3.17%) | 2(3.13%) | 0(0) | 0(0) | 3(1.78%) |
低危型 | ||||||||
11型 | 13(0.62%) | 12(0.70%) | 0(0) | 1(1.59%) | 0(0) | 0(0) | 0(0) | 0(0) |
42型 | 47(2.23%) | 43(2.51%) | 0(0) | 1(1.59%) | 2(3.13%) | 0(0) | 0(0) | 1(0.59%) |
43型 | 33(1.57%) | 30(1.75%) | 0(0) | 1(1.59%) | 1(1.56%) | 0(0) | 0(0) | 1(0.59%) |
44型 | 32(1.52%) | 26(1.52%) | 2(4.65%) | 0(0) | 1(1.56%) | 0(0) | 0(0) | 3(1.78%) |
6型 | 19(0.9%) | 18(1.05%) | 0(0) | 0(0) | 0(0) | 0(0) | 0(0) | 1(0.59%) |
合计 | 2 105(100%) | 1 713(100%) | 43(100%) | 63(100%) | 64(100%) | 6(100%) | 47(100%) | 169(100%) |
[1] |
Chinchai T, Chansaenroj J, Swangvaree S, et al. Prevalence of human papillomavirus genotypes in cervical cancer[J]. Int J Gynecol Cancer, 2012, 22(6):1063-1068.
doi: 10.1097/IGC.0b013e318259d904 URL |
[2] | 赵超, 李静, 屠铮, 等. 北京社区妇女生殖道人乳头瘤病毒感染及子宫颈上皮内瘤变流行病学调查[J]. 中华流行病学杂志, 2007, 28(10):947-950. |
[3] | 缪应新, 甘洁民, 陈洁, 等. 上海地区人乳头瘤病毒基因芯片法分型检测的临床意义[J]. 检验医学, 2015, 30(6):595-598. |
[4] |
Zhao Y, Wu K, Tong H, et al. Genotype patterns and prevalence of human papilloma virus in non-vaccinated women in Zunyi, China[J]. Saudi Med J, 2018, 39(6):572-578.
doi: 10.15537/smj.2018.6.22132 pmid: 29915851 |
[5] |
Yeo-Teh NSL, Ito Y, Jha S. High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis[J]. Int J Mol Sci, 2018, 19(6):1706.
doi: 10.3390/ijms19061706 URL |
[6] |
Tjalma WA, Depuydt CE. Cervical cancer screening: which HPV test should be used--L1 or E6/E7?[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 170(1):45-46.
doi: 10.1016/j.ejogrb.2013.06.027 pmid: 23932300 |
[7] |
Burd EM. Human papillomavirus and cervical cancer[J]. Clin Microbiol Rev, 2003, 16(1):1-17.
doi: 10.1128/CMR.16.1.1-17.2003 URL |
[8] |
Walboomers JM, Jacobs MV, Manos MM, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide[J]. J Pathol, 1999, 189(1):12-19.
doi: 10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F pmid: 10451482 |
[9] |
Wei B, Mei P, Huang S, et al. Evaluation of the sureX HPV genotyping test for the detection of high-risk HPV in cervical cancer screening[J]. Virol J, 2020, 17(1):171.
doi: 10.1186/s12985-020-01417-8 URL |
[10] | 黄路遥, 许燕燕, 娄晓丽, 等. 上海市松江区人乳头瘤病毒感染情况分析[J]. 检验医学, 2017, 32(8):695-699. |
[11] | 肖林林, 赵卫卫, 彭攸, 等. 区域内HPV亚型分布特点及其与宫颈病变的关系[J]. 国际检验医学杂志, 2017, 38(3):360-362,365. |
[12] |
Wang R, Guo XL, Wisman GB, et al. Nationwide prevalence of human papillomavirus infection and viral genotype distribution in 37 cities in China[J]. BMC Infect Dis, 2015, 15:257.
doi: 10.1186/s12879-015-0998-5 URL |
[13] | 姜丹, 叶劲东, 张晓平, 等. 深圳市万名流动妇女HPV感染现状分析[J]. 中国公共卫生管理, 2012, 28(6):796-798. |
[14] | Li J, Kang LN, Qiao YL. Review of the cervical cancer disease burden in mainland China[J]. Asian Pac J Cancer Prev, 2011, 12(5):1149-1153. |
[15] |
Zhao R, Zhang WY, Wu MH, et al. Human papillomavirus infection in Beijing, People′s Republic of China: a population-based study[J]. Br J Cancer, 2009, 101(9):1635-1640.
doi: 10.1038/sj.bjc.6605351 URL |
[16] |
Althoff KN, Paul P, Burke AE, et al. Correlates of cervicovaginal human papillomavirus detection in perimenopausal women[J]. J Womens Health (Larchmt), 2009, 18(9):1341-1346.
doi: 10.1089/jwh.2008.1223 pmid: 19702476 |
[17] | 李霓, 张思维, 陈万青, 等. 亚洲妇女宫颈癌中人乳头状瘤病毒型别分布的Meta分析[J]. 中国肿瘤, 2010, 19(3):195-202. |
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