Journal of Diagnostics Concepts & Practice ›› 2022, Vol. 21 ›› Issue (03): 317-325.doi: 10.16150/j.1671-2870.2022.03.005
• Original articles • Previous Articles Next Articles
LIU Peng, YAN Fuhua, QIN Le, XIAO Ruijie()
Received:
2022-01-05
Online:
2022-06-25
Published:
2022-08-17
Contact:
XIAO Ruijie
E-mail:xrj40702@rjh.com.cn
CLC Number:
LIU Peng, YAN Fuhua, QIN Le, XIAO Ruijie. Study on correlation of cardiac magnetic resonance strain rate parameters of left ventricular diastolic function with risk of sudden death in hypertrophic cardiomyopathy[J]. Journal of Diagnostics Concepts & Practice, 2022, 21(03): 317-325.
指南 | 风险评估因素 |
---|---|
2014版ESC指南 | 5年风险率=1-0.998exp(预后指数) 其中,预后指数=[0.159 398 58 × 左室壁最大厚度(mm)] - [0.002 942 71 × 左室壁最大厚度2(mm2)] + [0.025 908 2 × 左房直径(mm)] + [0.004 461 31 × 最大静息下左室流出道压差(mmHg)] + [0.458 308 2 × 心源性猝死家族史] + [0.826 391 95 × 非持续性室性心动过速] + [0.716 503 61 × 无法解释的晕厥] - [0.017 999 34 × 临床评估年龄(岁)] |
2020版ACC/AHA指南 | ①心源性猝死家族史;②最大左室壁厚度≥30 mm;③无法解释的晕厥;④非持续性室性心动过速;⑤延迟强化/左室心肌质量≥15%;⑥终末期左室射血分数<50%;⑦左室心尖部室壁瘤 |
基线特征 | HCM患者 (n=160) | 对照组 (n=50) | P值 |
---|---|---|---|
年龄(岁) | 53.96±15.21 | 52.45±11.01 | 0.561 |
性别 | 97(60.63) | 30(60.00) | 0.937 |
高血压 | 108(67.50) | 0(0) | <0.001 |
高脂血症 | 59(36.88) | 0(0) | <0.001 |
糖尿病 | 17(10.63) | 0(0) | <0.001 |
心源性猝死家族史 | 8(5.00) | 0(0) | <0.001 |
非持续性室性心动过速 | 5(3.13) | 0(0) | <0.001 |
无法解释的晕厥 | 21(13.13) | 0(0) | <0.001 |
二尖瓣反流 | 123(76.88) | 0(0) | <0.001 |
左心室舒张末期容积(mL) | 102.62±12.12 | 105.34±10.33 | 0.514 |
左心室收缩末期容积(mL) | 22.52±7.61 | 29.44±7.45 | <0.001 |
左心室射血分数(%) | 75.51±5.94 | 70.46±6.44 | <0.001 |
主要危险因素 | D-RSR(s-1) | t值 | P值 | D-CSR(s-1) | t值 | P值 | D-LSR(s-1) | t值 | P值 |
---|---|---|---|---|---|---|---|---|---|
MLVWT<30 mm(n=129) | -1.37±0.60 | 4.57 | <0.001 | 0.74±0.24 | -3.74 | <0.001 | 0.55±0.21 | -3.17 | <0.001 |
MLVWT≥30 mm(n=31) | -0.85±0.41 | 0.57±0.21 | 0.40±0.33 | ||||||
左房直径<40 mm(n=27) | -1.41±0.69 | 1.38 | 0.169 | 0.77±0.28 | -1.58 | 0.117 | 0.52±0.27 | 0.04 | 0.965 |
左房直径≥40 mm(n=133) | -1.24±0.58 | 0.69±0.23 | 0.52±0.24 | ||||||
左室流出道压差<30 mmHG(n=56) | -1.14±0.60 | -1.99 | 0.048 | 0.68±0.27 | 1.17 | 0.244 | 0.51±0.22 | 0.60 | 0.548 |
左室流出道压差≥30 mmHG(n=104) | -1.34±0.60 | 0.72±0.23 | 0.53±0.25 | ||||||
LGE/LVM比值<15%(n=87) | -1.46±0.63 | 4.63 | <0.001 | 0.77±0.24 | -3.56 | <0.001 | 0.55±0.24 | -1.77 | 0.024 |
LGE/LVM比值≥15%(n=73) | -1.04±0.49 | 0.64±0.22 | 0.49±0.24 |
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