Objective: To detect and analyze the chromosome karyotype in infertile patients. Methods: Lymphocyte culture and harvesting was performed according to the standard method, karyotypes were analyzed by G-banding in all cases and C-banding in some cases in addition. Results: One hundred and seven cases were detected having abnormal karyotypes from all 5 067 infertility cases and the detection rate was 2.11%, 207 cases were detected having polymorphism and the positive rate was 4.09%, both were higher than those among normal population. The incidence of chromosomal abnormalities was similar between males and females, however, the abnormal sex chromosome number had a higher positive rates in men than in women, while there was more low level mixed chimerism in women (P<0.05). In addition, there were higher detection rates of chromosome secondary constriction and chromosome 9 inversion. The negative impact of polymorphism on reproduction should be paid attention. Conclusions: Chromosomal abnormalities or polymorphism is one of the important causes for infertility and history of adverse pregnancy.
FAN Weimin, CHENG Meiyu, SI Chenchen, ZHANG Aijun
. Karyotype analysis of 5 067 infertile patients[J]. Journal of Diagnostics Concepts & Practice, 2017
, 16(03)
: 282
-286
.
DOI: 10.16150/j.1671-2870.2017.03.010
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