Journal of Diagnostics Concepts & Practice ›› 2017, Vol. 16 ›› Issue (03): 282-286.doi: 10.16150/j.1671-2870.2017.03.010

• Original articles • Previous Articles     Next Articles

Karyotype analysis of 5 067 infertile patients

FAN Weimin, CHENG Meiyu, SI Chenchen, ZHANG Aijun   

  1. The Center of Reproductive Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2017-05-30 Online:2017-06-25 Published:2017-06-25

Abstract: Objective: To detect and analyze the chromosome karyotype in infertile patients. Methods: Lymphocyte culture and harvesting was performed according to the standard method, karyotypes were analyzed by G-banding in all cases and C-banding in some cases in addition. Results: One hundred and seven cases were detected having abnormal karyotypes from all 5 067 infertility cases and the detection rate was 2.11%, 207 cases were detected having polymorphism and the positive rate was 4.09%, both were higher than those among normal population. The incidence of chromosomal abnormalities was similar between males and females, however, the abnormal sex chromosome number had a higher positive rates in men than in women, while there was more low level mixed chimerism in women (P<0.05). In addition, there were higher detection rates of chromosome secondary constriction and chromosome 9 inversion. The negative impact of polymorphism on reproduction should be paid attention. Conclusions: Chromosomal abnormalities or polymorphism is one of the important causes for infertility and history of adverse pregnancy.

Key words: Chromosomal abnormalities, Polymorphism, Infertility

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