Journal of Diagnostics Concepts & Practice >
Perfomence of MRI intravoxel incoherent motion diffusion weighted imaging parameters in diagnosing active Crohn's disease
Received date: 2019-10-10
Online published: 2020-04-25
Objective: To explore the performance of MRI intravoxel incoherent motion diffusion weighted imaging(IVIM-DWI) parameters in diagnosing active Crohn′s disease(CD). Methods: The MRI IVIM-DWI scan was performed on 30 patients with active ileocolonic CD diagnosed by endoscopy. The IVIM-DWI parameters, including apparent diffusion coefficient(ADC), diffusion coefficient of the true water molecule (D), microcirculation perfusion coefficient (D*) and perfusion fraction(f), within the walls of involved ileocolon (CD group ) and normal intestinal at the same level (control group) were determined. The parameters were compared between CD and control groups. Receiver operator characteristic(ROC) analysis was performed to evaluate the diagnostic performance of each parameter. Results: ADC, D* and f values in CD group were significantly lower than those in control group (P<0.05). There was no statistically significant difference in D values between the two groups(P>0.05). The optimal cut-off value of ADC, D*, f for diagnosing CD were 1.00×10-3 mm2/s, 26.50×10-3 mm2/s, 40.4%, with the area under the ROC curves of 0.952, 0.726, 0.799, respectively. Conclusion: MRI intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) parameters, such as ADC, D*and f values, are helpful for diagnosis of active CD, and ADC value has the highest diagnostic performance.
WU Shuang, XIE Qian, GUAN Xueni, ZHANG Sufang, GAO Xinfang, LIANG Zonghui . Perfomence of MRI intravoxel incoherent motion diffusion weighted imaging parameters in diagnosing active Crohn's disease[J]. Journal of Diagnostics Concepts & Practice, 2020 , 19(02) : 157 -161 . DOI: 10.16150/j.1671-2870.2020.02.011
[1] | Baumgart DC, Sandborn WJ. Crohn's disease[J]. Lancet, 2012, 380(9853):1590-1605. |
[2] | Tolan DJ, Greenhalgh R, Zealley IA, et al. MR enterographic manifestations of small bowel Crohn disease[J]. Radiographics, 2010, 30(2):367-384. |
[3] | 中华医学会消化病学分会炎症性肠病学组. 炎症性肠病诊断与治疗的共识意见(2018 年,北京)[J]. 中华消化杂志,2018, 38(5):292-311. |
[4] | Oto A, Kayhan A, Williams JT, et al. Active Crohn's di-sease in the small bowel: evaluation by diffusion weigh-ted imaging and quantitative dynamic contrast enhanced MR imaging[J]. J Magn Reson Imaging, 2011, 33(3):615-624. |
[5] | Li XH, Sun CH, Mao R, et al. Diffusion-weighted MRI enables to accurately grade inflammatory activity in patients of ileocolonic Crohn's disease: Results from an observational study[J]. Inflamm Bowel Dis, 2017, 23(2):244-253. |
[6] | Oto A, Zhu F, Kulkarni K, et al. Evaluation of diffusion-weighted MR imaging for detection of bowel inflammation in patients with Crohn's disease[J]. Acad Radiol, 2009, 16(5):597-603. |
[7] | Luciani A, Vignaud A, Cavet M, et al. Liver cirrhosis: intravoxel incoherent motion MR imaging--pilot study[J]. Radiology, 2008, 249(3):891-899. |
[8] | Carr ND, Pullan BR, Schofield PF. Microvascular studies in non-specific inflammatory bowel disease[J]. Gut, 1986, 27(5):542-549. |
[9] | Hultén L, Lindhagen J, Lundgren O, et al. Regional intestinal blood flow in ulcerative colitis and Crohn's di-sease[J]. Gastroenterology, 1977, 72(3):388-396. |
[10] | Pan F, Den J, Zhang C, et al. The therapeutic response of gastrointestinal stromal tumors to imatinib treatment assessed by intravoxel incoherent motion diffusion-weighted magnetic resonance imaging with histopatholo-gical correlation[J]. PLoS One, 2016, 11(12):e0167720. |
[11] | Klauβ M, Maier-Hein K, Tjaden C, et al. IVIM DW-MRI of autoimmune pancreatitis: therapy monitoring and differentiation from pancreatic cancer[J]. Eur Radiol, 2016, 26(7):2099-2106. |
[12] | Hectors SJ, Gordic S, Semaan S, et al. Diffusion and perfusion MRI quantification in ileal Crohn's disease[J]. Eur Radiol, 2019, 29(2):993-1002. |
/
〈 |
|
〉 |