Original articles

The correlation between different fat distribution indices and dyslipidemia in middle-aged population in Shanghai

Expand
  • 1. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    2. Songnan Community Health Service Center, Baoshan District, Shanghai 200441, China

Received date: 2018-01-30

  Online published: 2019-04-25

Abstract

Objective: To investigate the correlation between different fat distribution indices and dyslipidemia in community residents of Songnan District in Shanghai. Methods: A survey was conducted among 550 community residents in Songnan District, Shanghai. Questionnaires was used to collect information on health status, medical history, and lifestyle. Subjects received physical examinations for height, body weight, waist circumference, and blood pressure measurement. Venous blood sample was collected after an overnight fast and blood lipids and glucose were tested. CT and FATSCAN software were used to measure abdominal visceral fat area and subcutaneous fat area. Results: The proportion of dyslipidemia among 550 community residents in Songnan District was 65.1%. Measures of fat distribution indices such as body-mass index (BMI), waist-hip ratio, waist circumference, visceral fat area, subcutaneous fat area in individuals with dyslipidemia were significantly higher than individuals with normal blood lipids (P<0.05). Multivariable logistic regression analysis showed that after adjustment for sex, age, current smoking, current drinking, educational attainment, systolic pressure, HbA1c, blood glucose-lowering treatment and insulin resistance, one-SD increase in waist-hip ratio was associa-ted with 87% increase in risks of having high LDL-cholesterol; one-SD increase in waist circumference was associated with 60% increase in risks of having low HDL-cholesterol and 45% increase in risks of having dyslipidemia. Conclusions: Most indicators of fat distribution such as BMI, waist-hip ratio, waist circumference, visceral fat area, and subcutaneous fat area are correlated with dyslipidemia, however, the degree of correlation is different. Waist-hip ratio might be more important in the association with high LDL-cholesterol. Waist circumference might be more important in the association with low HDL-cholesterol and dyslipidemia.

Cite this article

WANG Shanshan, ZHOU Yingxia, HU Lijuan, NIU Jingya, WANG Tiange, LI Mian, ZHAO Zhiyun, XU Yu, LU Jieli, XU Min, BI Yufang, NI Hengru . The correlation between different fat distribution indices and dyslipidemia in middle-aged population in Shanghai[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(2) : 177 -182 . DOI: 10.16150/j.1671-2870.2019.02.011

References

[1] Tian Y, Jiang C, Wang M, et al. BMI, leisure-time physical activity, and physical fitness in adults in China: results from a series of national surveys, 2000-14[J]. Lancet Diabetes Endocrinol, 2016, 4(6):487-497.
[2] Yang W, Xiao J, Yang Z, et al. Serum lipids and lipoproteins in Chinese men and women[J]. Circulation, 2012, 125(18):2212-2221.
[3] 朱斐. 中国正常体重人群脂肪及其分布与代谢异常的研究[D]. 浙江大学, 2012.
[4] 中国成人血脂异常防治指南制订联合委员会. 中国成人血脂异常防治指南[J]. 中华心血管病杂志, 2007, 35(5):390-419.
[5] WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies[J]. Lancet, 2004, 363(9403):157-163.
[6] Li R, Shi L, Jia J, et al. Differentiating the associations of waist circumference and body mass index with cardiovascular disease risk in a Chinese population[J]. Asia Pac J Public Health, 2015, 27(2):NP457-NP467.
[7] Janssen I, Katzmarzyk PT, Ross R. Waist circumference and not body mass index explains obesity-related health risk[J]. Am J Clin Nutr, 2004, 79(3):379-384.
[8] Dalton M, Cameron AJ, Zimmet PZ, et al. Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults[J]. J Intern Med. 2003 Dec; 254(6):555-663.
[9] 刘春燕, 高玉琪, 徐元仁, 等. 肥胖病妇女的脂肪分布与血清脂质成分的相关分析[J]. 天津医药, 2006, 34(8):539-541.
[10] Neeland IJ, Ayers CR, Rohatgi AK, et al. Associations of visceral and abdominal subcutaneous adipose tissue with markers of cardiac and metabolic risk in obese adults[J]. Obesity (Silver Spring), 2013, 21(9):E439-E447.
[11] Avramoglu RK, Qiu W, Adeli K. Mechanisms of metabolic dyslipidemia in insulin resistant states: deregulation of hepatic and intestinal lipoprotein secretion[J]. Front Biosci, 2003, 8:d464-d476.
[12] 娄路馨, 王玲, 李娜, 等. 定量CT测量的腹部脂肪分布与血脂和血糖的关系[J]. 中国骨质疏松杂志, 2012, 18(11):1004-1007.
[13] Sadeghi M, Pourmoghaddas Z, Hekmatnia A, et al. Abdominal fat distribution and serum lipids in patients with and without coronary heart disease[J]. Arch Iran Med, 2013, 16(3):149-153.
Outlines

/