Objective: To study the efficacy of microteaching method in the teaching of clinical diagnosis. Methods: A total of 280 students in 8-year program or 5-year program were divided into the testing group and control group: students in testing group were instructed with the microteaching method and students in control group were instructed with the conventional method. At the end of course, the teaching efficiency of the two groups were evaluated. Results: The academic records and learning satisfaction were all better in the testing group than those in control group. Conclusions: Microteaching method could enhance students' subjective initiation, learning ability and practice capability.