Journal of Diagnostics Concepts & Practice >

2019 , Vol. 18 >Issue 05: 570 - 574

DOI: https://doi.org/10.16150/j.1671-2870.2019.05.016

Original articles

The potential value of serum pepsinogen in screening of chronic atrophic gastritis among population with high risk for gastric cancer of Shanghai central urban area

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  • 1. Department of Gastroenterology, Jing'an District Central Hospital, Fudan University, Shanghai 200040, China
    2. General Practitioner of Traditional Chinese Medicine, Community Health Service Center, 2nd Shimen Road, Jin'an District, Shanghai 200041, China
    3. Department of Radiology Center for Community Health Service, West Nanjing Road Sub-District, Jin'an District, Shanghai 200041, China

Received date: 2019-08-20

  Online published: 2019-10-25

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Abstract

Objective: To evaluate the value of measurement of serum pepsinogen(PG) for the screening of chronic atrophic gastritis(CAG) in gastric cancer high risk people. Methods: A symptomatic subjects with high risk for gastric cancer lived in Shanghai central urban area were enrolled to measure serum PG, Helicobacter pylori antibody and conduct endoscopy and biopsy. According to histological results, CAG were divided to no atrophy group, antrum predominant group, corpus predominant group and entire stomach gastricatrophy group. Results: Of the 178 cases enrolled, corpus predominant group and entire stomach group exhibited a significantly lower PGR（PGⅠ∶Ⅱ ratio）when compared with the no atrophy group and antrumpredominant group (P<0.05). The cut-off value of PGR ≤5.16 demonstrated a sensitivity of 91.8%, specificity of 61.9% and area under the receiver operating characteristic curve 0.794 in detecting entire stomach gastric atrophy. The cut-off value of PGR ≤6.43 demonstrated a sensitivity of 78.7%, specificity of 65.5% and area under the receiver operating characteristic curve 0.750 in detecting entire stomach gastric atrophy. Conclusions: Serum PGR is a sensitive and specific marker for detecting corpus involved CAG. PGR might be potentially used as a non-invasive biomarker for detecting CAG among population with high risk for gastric cancer.

Key words： Atrophic gastritis; Pepsinogens; Gastric cancer

Cite this article

ZHOU Lei, WANG Hong, XU Huiming, YE Tao, GAO Jianping, SUN Yijun, XIE Jun . The potential value of serum pepsinogen in screening of chronic atrophic gastritis among population with high risk for gastric cancer of Shanghai central urban area[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(05) : 570 -574 . DOI: 10.16150/j.1671-2870.2019.05.016

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