Journal of Diagnostics Concepts & Practice >

2019 , Vol. 18 >Issue 1: 37 - 43

DOI: https://doi.org/10.16150/j.1671-2870.2019.01.008

Original articles

A prospective study on incidence of chronic thromboembolic pulmonary hypertension after pulmonary thromboembolism

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  • 1. Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
    2. Department of Respiratory, North Branch, Huashan University, Shanghai 201907, China
    3. Department of Respiratory, Affiliated Hospital, Shanxi Normal University, Shanxi Xi′an 710061, China

Received date: 2019-01-31

  Online published: 2019-02-25

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Abstract

Objective: To explore the incidence of chronic thromboembolic pulmonary hypertension (CTEPH) in a series of patients with symptomatic pulmonary embolism(PE) diagnosed for the first time and receiving adequate anticoagulant treatment no less than 3 months, and to assess the risk factors of CTEPH in these patients. Methods: A prospective, long-term, 3 years follow-up study was conducted to assess the incidence and risk factors of CTEPH in 292 patients with PE diagnosed for the first time. Results: The cumulative incidence of CTEPH in 292 patients with PE diagnosed for the first time was 9.20% at three months, 10.40% at six months, 11.30% at one year, 11.90% at two years, and 12.90% at three years. The following factors increased the risk of CTEPH: time from symptoms to treatment of PE≥1 month (odds ratio OR=9.065), the intermediate risk PE (OR, 37.691) to high risk PE (OR=33.957); segmental and sub-segmental branch location of embolism (OR=6.216), the PE related primary risk factors (OR=3.659). Conclusions: The cumulative incidence of CTEPH in patients with PE is 12.90% at three years.CTEPH is a common complication in PE patients diagnosed for the first time.

Key words： pulmonary embolism; chronic thromboembolic pulmonary hypertension; risk factors; umulative incidence

Cite this article

WEI Xiaomin, ZHANG Yuanyuan, DONG Liang, XIA Jingwen, GONG Yi, YU Yongping, LI Shengqing . A prospective study on incidence of chronic thromboembolic pulmonary hypertension after pulmonary thromboembolism[J]. Journal of Diagnostics Concepts & Practice, 2019 , 18(1) : 37 -43 . DOI: 10.16150/j.1671-2870.2019.01.008

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