Objective: To study the expression of Epstein-Barr virus (EBV) autoantibodies and IL-17, IL-23 in cerebrospinal fluid of patients with multiple sclerosis (MS) and to define the relationship between IL-17/IL-23 and pathogenesis of MS for hoping to provide a diagnostic reference for clinical practice. Methods: Seventy-two patients with neurological diseases in Ruijin Hospital were categorized into 2 groups: 29 cases with central nervous system autoimmune disease (study group) and 43 cases of non-central nervous system autoimmune disease (control group). Enzyme-linked immunosorbent assay (ELISA) was used to assess the levels of EBV-VCA-IgM, EBV-EBNA-1IgG, IL-17, IL-23 in CSF. Results: The expressions of EBV-EBNA-1IgG, EBV-VCA IgM and IL-23 in study group were significantly higher than those in control group (P<0.01). In study group, the expression of IL-23 in MS patients was significantly higher than that in control group（P<0.01), and the expression of IL-17 in MS patients was higher than that in control group（P<0.05）. Conclusions: EBV is related to MS and probably contributes to the pathogenesis of MS. Meanwhile, the abnormal inflammatory axis of IL-17/IL-23 may also be related to the induction of MS. The study indicates a relationship of MS not only with viral infection, but also with a disordered autoimmune system.
MENG Jun, PENG Yibing, WANG Xuefeng, CHEN Ninan, ZHANG Dongqing
. A study on correlation between multiple sclerosis and Epstein-Barr virus and IL-17/IL-23[J]. Journal of Diagnostics Concepts & Practice, 2017
, 16(01)
: 88
-92
.
DOI: 10.16150/j.1671-2870.2017.01.017
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