内科理论与实践

内科理论与实践 ›› 2024, Vol. 19 ›› Issue (06): 367-371.doi: 10.16138/j.1673-6087.2024.06.03

• 专家论坛 • 上一篇    下一篇

皮肤病理学检查在风湿免疫性疾病诊断中的作用

陈佳1(), 赵福涛2, 孙建方3   

  1. 1.同济大学附属皮肤病医院风湿免疫科，上海 200443
    2.上海交通大学医学院附属第九人民医院风湿免疫科，上海 200011
    3.中国医学科学院北京协和医学院皮肤病医院/皮肤病研究所病理科，江苏 南京 210042
  • 收稿日期:2024-11-13 出版日期:2024-12-26 发布日期:2025-03-11
  • 通讯作者: 陈佳 E-mail：1500155@tongji.edu.cn

Role of dermatopathology in diagnosis of rheumatic diseases

CHEN Jia1(), ZHAO Futao2, SUN Jianfang3   

  1. 1. Department of Rheumatology, Skin Disease Hospital of Tongji University, Shanghai 200443, China
    2. Department of Rheumatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
    3. Department of Pathology, Hospital for Skin Disease, Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing 210042, China
  • Received:2024-11-13 Online:2024-12-26 Published:2025-03-11

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摘要：

皮肤组织病理学检查是皮损诊断的“金标准”，可帮助有皮损表现的风湿免疫性疾病作出尽量精准的诊断。大多数风湿免疫性疾病皮损病理表现特异性不高，盘状红斑狼疮（discoid lupus erythematosus, DLE）、硬皮病、成人Still病、血管炎等皮损组织病理学特征相对鲜明。皮肤病理检查在风湿免疫性疾病原发病诊断、合并症鉴别、疾病分型分期、发病机制探讨等方面有不同程度的作用。正确掌握和应用皮肤病理检查技术，有助于风湿免疫性疾病的精准诊疗。

关键词: 皮肤病理, 风湿免疫性疾病, 系统性红斑狼疮

Abstract:

Dermatopathological examination is the “gold standard” for skin lesion diagnosis, which can help to make the most accurate diagnosis of rheumatic immune diseases with skin lesions. The dermatopathological manifestations of skin lesions in most rheumatic diseases are not very specific, while the dermatohistopathological features are relatively distinct in discoid lupus erythematosus, scleroderma, adult Still disease and vasculitis. Dermatopathology plays different roles in the diagnosis of rheumatic immune diseases, differentiation of comorbidities, disease classification and staging, and exploration of pathogenesis of rheumatic diseases. Mastering and applying dermatopathological techniques are very important for the precise diagnosis and treatment of rheumatic diseases.

Key words: Dermatopathology, Rheumatic diseases, Systemic lupus erythematosus

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