基于嵌合抗原受体细胞疗法在自身免疫性疾病中应用的前景

doi:10.16138/j.1673-6087.2024.06.02

摘要/Abstract

摘要：

近年来细胞疗法作为一种新兴的免疫治疗方法，在血液肿瘤治疗领域取得了显著成效。然而，将嵌合抗原受体（chimeric antigen receptor, CAR）细胞疗法应用于自身免疫性疾病仍是相对新颖且具有挑战性的方向。自身免疫性疾病是由于个体的免疫系统错误地攻击自身组织引起，其病因复杂、症状多样，目前传统治疗方法及生物制剂治疗仍不能满足临床需求。CAR细胞疗法通过工程化T细胞、NK细胞、巨噬细胞等免疫细胞，使其特异性识别并杀伤特定抗原表达的细胞，具有高度靶向性和持久性，为治疗自身免疫性疾病提供新希望。本文将系统阐述基于CAR细胞疗法在治疗自身免疫性疾病中的最新研究进展及其面临的挑战，如安全性、免疫应答调控以及临床应用中的难点。

关键词: 嵌合抗原受体, 细胞疗法, 自身免疫性疾病, 安全性, 临床应用

Abstract:

In recent years, chimeric antigen receptor (CAR) cell therapy, as an emerging immunotherapy method, has achieved significant results in the field of hematological cancer treatment. However, applying CAR cell therapy to autoimmune diseases remains a relatively novel and challenging method. Autoimmune diseases are caused by an individual’s immune system mistakenly attacking their own tissues, and their complex etiology and diverse symptoms make traditional treatment methods and biologics still unable to meet clinical needs. CAR cell therapy, using engineering T cells or other immune cells to recognize and kill specific antigens, is highly targeted and durable, which providing new hope for the treatment of autoimmune diseases. This article systematically reviews the latest research progress and challenges of using CAR cell therapy in the treatment of autoimmune diseases, such as safety, immune response issues, and difficulties in clinical application.

Key words: Chimeric antigen receptor, Cell therapy, Autoimmune diseases, Safety, Clinical application

中图分类号:

R593.2

高洁. 基于嵌合抗原受体细胞疗法在自身免疫性疾病中应用的前景[J]. 内科理论与实践, 2024, 19(06): 363-366.

GAO Jie. Prospects and challenges of applying chimeic antigen receptor cell therapy in autoimmune diseases[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(06): 363-366.

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