内科理论与实践

内科理论与实践 ›› 2025, Vol. 20 ›› Issue (03): 198-203.doi: 10.16138/j.1673-6087.2025.03.03

• 论著 • 上一篇    下一篇

内镜逆行胰胆管造影术在青少年慢性胰腺炎及并发症治疗中的应用

黄云1,2, 别理克·扣肯1, 黄佳1, 姚玮艳1, 朱颖1()   

  1. 1.上海交通大学医学院附属瑞金医院消化内科，上海 200025
    2.青海大学附属医院消化内科，青海 西宁 810000
  • 收稿日期:2025-02-18 出版日期:2025-06-28 发布日期:2025-09-01
  • 通讯作者: 朱颖 E-mail:zy10871@rjh.com.cn
  • 基金资助:
    2023年度青海大学青年科研基金医学类项目[2023-QYY-5]

Application of endoscopic retrograde cholangiopancreatography in treatment of adolescent patients with chronic pancreatitis and complications

HUANG Yun1,2, BIELIKE Kouken1, HUANG Jia1, YAO Weiyan1, ZHU Yin1()   

  1. 1. Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    2. Department of Gastroenterology, Hospital of Qinghai University, Xining 810000, China
  • Received:2025-02-18 Online:2025-06-28 Published:2025-09-01
  • Contact: ZHU Yin E-mail:zy10871@rjh.com.cn

RichHTML

2

PDF (PC)

1

摘要：

目的：探讨内镜逆行胰胆管造影术（endoscopic retrograde cholangiopancreatography, ERCP）在青少年慢性胰腺炎（chronic pancreatitis, CP）及其并发症治疗中的临床应用价值。 方法：方法：采用回顾性分析，收集2023年1月至2024年12月期间在上海交通大学医学院附属瑞金医院消化科就诊并住院治疗的104例青少年CP及并发症患者的临床资料。根据治疗方式将患者分为ERCP组（接受ERCP治疗）和对照组（接受非ERCP治疗），比较2组患者的治疗效果、安全性指标、半年内复发率以及生活质量评分。 结果：ERCP组68例，对照组36例。2组患者在年龄、疾病特点及治疗前视觉模拟法（visual analog scale，VAS）评分方面无显著差异（P分别为0.080、0.386、0.185），治疗前简明健康调查量表（12-item short form health survey，SF-12）评分差异具有统计学意义（P=0.025）。治疗前，2组VAS评分分别为（6.63±1.74）分和（6.26±1.08）分；治疗后，ERCP组VAS评分[（2.57±0.64）分]显著低于对照组[（4.63±0.79）分]（P<0.001）。治疗前，2组SF-12评分分别为（44.57±8.09）分和（49.36±11.02）分，治疗后分别为（84.65±9.27）分和（69.16±7.75）分，治疗后ERCP组SF-12评分显著高于对照组（P<0.001）。此外，2组半年内复发率分别为14.08%和36.11%，并发症发生率分别为1.47%和8.33%，差异均有统计学意义。 结论：青少年CP及并发症患者选择ERCP治疗（尤其是胰管结石取出，胰管支架置入），可有效缓解临床症状，提高生活质量，手术操作成功率高，疗效确切，并发症发生率低。

关键词: 胰管结石取出术, 胰管支架置入术, 胰腺炎疼痛缓解, 青少年患者

Abstract:

Objective To explore the clinical application value of endoscopic retrograde cholangiopancreatography (ERCP) in the treatment of chronic pancreatitis and its complications in adolescents. Methods The clinical data of 104 adolescent patients with chronic pancreatitis and complications who were admitted to the Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine from January 2023 to December 2024 were collected and a retrospective analysis was conducted. The patients were divided into the ERCP group (receiving ERCP treatment) and the control group (receiving conventional treatment) based on the treatment methods. The treatment effects, safety indicators, recurrence rates within six months, and scores of quality of life were compared between the two groups. Results There were 68 cases in the ERCP group and 36 cases in the control group. The two groups showed no significant differences in age, disease characteristics, and pre-treatment visual analogue scale (VAS) scores (P=0.080, 0.386, and 0.185, respectively), while the difference in 12-item short form health survey (SF-12) scores before treatment were significant (P=0.025). Before treatment, the VAS scores of the two groups were 6.63±1.74 and 6.26±1.08, respectively (P>0.05). After treatment, the VAS score in the ERCP group (2.57±0.64) was significantly lower than that in the control group (4.63±0.79) (P<0.001). Before treatment, the SF-12 scores of the two groups were 44.57±8.09 and 49.36±11.02, respectively (P>0.05); after treatment, the SF-12 score in the ERCP group (84.65±9.27) was significantly higher than that in the control group (69.16±7.75) (P<0.001). In addition, the recurrence rates within six months were 14.08% (ERCP group) and 36.11% (control group), and complication rates were 1.47% (ERCP group) and 8.33% (control group), which showed significant differences. Conclusions For adolescent patients with cholangiopancreatography and its complications, ERCP (especially pancreatic duct stone removal and stent placement) effectively alleviates clinical symptoms, improves quality of life, and shows high success rates with a low incidence of complications.

Key words: Pancreatic duct stone removal, Stent placement, Pain relief in pancreatitis, Adolescent patients

中图分类号: