以假性肠梗阻为首发表现的干燥综合征1例

doi:10.16138/j.1673-6087.2025.04.11

内科理论与实践 ›› 2025, Vol. 20 ›› Issue (04): 319-321.doi: 10.16138/j.1673-6087.2025.04.11

以假性肠梗阻为首发表现的干燥综合征1例

刘美兰^a, 王领^a, 杨蓉^a, 王嘉乐^a, 涂慧敏^a, 李慧凛^a^,^b()

a.上海市浦东新区公利医院风湿免疫科, 上海 200135
b.上海市浦东新区公利医院肾脏内科, 上海 200135

收稿日期:2024-11-20 出版日期:2025-07-31 发布日期:2025-10-27
通讯作者: 李慧凛 E-mail: medlhl@163.com
基金资助:
上海市浦东新区卫生健康委员会领先人才培养计划(PWRl2024-01);上海市浦东新区卫生健康委员会2025年度科教兴医培育学科建设类项目(PWZbr2025-03)

A case of Sjögren syndrome with intestinal pseudo-obstruction as the initial symptom

LIU Meilan^a, WANG Ling^a, YANG Rong^a, WANG Jiale^a, TU Huimin^a, LI Huilin^a^,^b()

a. Department of Rheumatology & Immunology, Shanghai Pudong New Area Gongli Hospital, Shanghai, 200135, China
b.Department of Nephrology, Shanghai Pudong New Area Gongli Hospital, Shanghai, 200135, China

Received:2024-11-20 Online:2025-07-31 Published:2025-10-27

摘要/Abstract

摘要：

干燥综合征（Sjögren syndrome, SS）是一种以外分泌腺受累为主的系统性自身免疫性疾病，临床表现多样，易被误诊。本文报道1例以假性肠梗阻（intestinal pseudo-obstruction, IPO）为首发症状的SS病例。患者为31岁女性，因恶心、呕吐伴排便停止就诊，影像学提示结肠积粪但无机械性梗阻证据，血清学检测显示抗SSA/SSB/Ro-52抗体阳性，唇腺活检符合SS特征。经糖皮质激素及免疫调节治疗后症状缓解。本病例提示，SS可表现为非典型胃肠及神经系统症状，临床中需结合自身抗体检测及多学科评估以提高诊断准确性。

关键词: 干燥综合征, 假性肠梗阻, 神经系统损害

Abstract:

Sjögren syndrome (SS) is a systemic autoimmune disease primarily affecting exocrine glands. It has diverse clinical manifestations and is easily misdiagnosed. This article reports a case of SS presenting with intestinal pseudo-obstruction (IPO) as the initial symptom. A 31-year-old female presented with nausea, vomiting and bowel movement cessation. Imaging revealed colonic fecal impaction without mechanical obstruction. Serological tests showed positive anti-SSA/SSB/Ro-52 antibodies, and labial gland biopsy confirmed SS. The patient’s symptoms were relieved after receiving glucocorticoid and immunomodulatory therapy. This case highlights that SS may present with atypical gastrointestinal and neurological symptoms, suggesting the importance of multidisciplinary evaluation and autoantibody screening for early diagnosis.

Key words: Sjögren syndrome, Intestinal pseudo-obstruction, Nervous system damage

中图分类号:

R593.2

刘美兰, 王领, 杨蓉, 王嘉乐, 涂慧敏, 李慧凛. 以假性肠梗阻为首发表现的干燥综合征1例[J]. 内科理论与实践, 2025, 20(04): 319-321.

LIU Meilan, WANG Ling, YANG Rong, WANG Jiale, TU Huimin, LI Huilin. A case of Sjögren syndrome with intestinal pseudo-obstruction as the initial symptom[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(04): 319-321.

图/表 2

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以假性肠梗阻为首发表现的干燥综合征1例

A case of Sjögren syndrome with intestinal pseudo-obstruction as the initial symptom

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