内科理论与实践

内科理论与实践 ›› 2025, Vol. 20 ›› Issue (01): 14-17.doi: 10.16138/j.1673-6087.2025.01.03

• 论著 • 上一篇    下一篇

口疮散治疗自体造血干细胞移植患者口腔黏膜炎疗效观察

唐暐a, 蔡铭慈a, 沈一格a, 张守杰b, 葛健c(), 赵维莅a()   

  1. 上海交通大学医学院附属瑞金医院 a.血液科 上海血液学研究所 医学基因组学国家重点实验室 国家转化医学中心; b.中医科; c.眼科，上海 200025
  • 收稿日期:2023-12-04 出版日期:2025-02-28 发布日期:2025-04-30
  • 通讯作者: 葛健,赵维莅 E-mail:gj10420@rjh.com.cn;zhao.weili@yahoo.com

Clinical effect of Kou Chuang San in treating oral mucositis associated with chemotherapy in malignant hematologic patient after autologous stem cell transplantation

TANG Weia, CAI Mingcia, SHEN Yigea, ZHANG Shoujieb, GE Jianc(), ZHAO Weilia()   

  1. a. Department of Hematology,Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine; b. Department of Traditional Chinese Medicine; c. Depowtment of Ophthalmology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Received:2023-12-04 Online:2025-02-28 Published:2025-04-30
  • Contact: GE Jian, ZHAO Weili E-mail:gj10420@rjh.com.cn;zhao.weili@yahoo.com

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摘要：

目的：探讨应用口疮散治疗自体造血干细胞移植患者口腔黏膜炎的效果。方法：回顾性分析2016年4月—2021年12月我院血液科接受自体造血干细胞移植的149例患者，根据是否使用口疮散治疗进行分组，治疗组在移植后第1天起应用口疮散外敷于口腔黏膜，未使用者为对照组。比较2组患者的口腔黏膜炎分级以及疗效。结果：口疮散治疗组及对照组的口腔黏膜炎患病率相近，治疗组口腔溃疡愈合率明显优于对照组（87.18%比6.25%，P<0.001），不同严重程度病例经口疮散治疗后均有效缓解。结论：口疮散治疗造血干细胞移植患者大剂量预处理化疗后口腔黏膜炎安全有效，值得临床推广。

关键词: 自体造血干细胞移植, 口腔黏膜炎, 口疮散

Abstract:

Objective To study clinical effect with Kou Chuang San in oral mucositis associated with chemotherapy in malignant hematologic patient during autologous stem cell transplantation. Methods From April 2016 to December 2021,149 patients with oral mucositis who received autologous hematopoietic stem cell transplantation in the Department of Hematology in Ruijin hospital were enrolled and divided into two groups according to receiving Kou Chuang San treatment or not. The treatment group was applied to Kou Chuang San on the first day after stem cell transplantation, while the patients who did not receive Kou Chuang San treatment belonged to the control group. Oral mucositis grading and therapeutic effects were compared between the two groups. Results The incidence of oral mucositis in the treatment group was significantly lower than that in the control group (87.18% vs 6.25%, P<0.001). Conclusions The Kou Chuang San is effective and safe in treating patients with oral mucositis after autologous hematopoietic stem cell transplantation.

Key words: Autologous stem cell transplantation, Oral mucositis, Kou Chuang San

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