细胞焦亡在肺部疾病中的研究进展

doi:10.16138/j.1673-6087.2025.05.14

摘要/Abstract

摘要：

细胞焦亡是近年来被发现并证实的一种新型细胞程序性死亡方式，其特征包括细胞内外渗透压改变、细胞膜破裂以及胞内促炎性物质释放，从而引发严重的炎症反应。近年来越来越多的证据表明细胞焦亡与肺部疾病的发生和发展密切相关，例如肺癌、支气管哮喘、慢性阻塞性肺疾病、肺损伤和肺动脉高压等。本文旨在对细胞焦亡在肺部疾病中的作用机制及其病理生理意义作一综述。

关键词: 细胞焦亡, 肺癌, 支气管哮喘, 慢性阻塞性肺疾病

Abstract:

Pyroptosis is a new type of programmed cell death discovered and confirmed in recent years. It is accompanied by changes in intracellular and extracellular osmotic pressure, cell rupture, and the leakage of pro-inflammatory substances, thereby leading to severe inflammatory reactions. In recent years, increased evidence has shown that pyroptosis is closely related to lung diseases, such as lung cancer, bronchial asthma, chronic obstructive pulmonary disease, lung injury, pulmonary arterial hypertension, etc. This article aims to review the role of pyroptosis and its pathophysiological relationship with lung diseases.

Key words: Pyroptosis, Lung cancer, Bronchial asthma, Chronic obstructive pulmonary disease

中图分类号:

R563.5

李贤梅, 李敏, 杨振宁, 李薇. 细胞焦亡在肺部疾病中的研究进展[J]. 内科理论与实践, 2025, 20(05): 420-425.

LI Xianmei, LI Min, YANG Zhenning, LI Wei. Research advances on pyroptosis in pulmonary diseases[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(05): 420-425.

图/表 1

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