Journal of Internal Medicine Concepts & Practice ›› 2021, Vol. 16 ›› Issue (03): 183-187.doi: 10.16138/j.1673-6087.2021.03.009
• Original article • Previous Articles Next Articles
LI Yanxiu1a, ZHU Enze2, ZHOU Chunlei3, LIU Yun1a, ZUO Xiangrong, LI Jinghang1b(), CAO Quan1a
Received:
2021-01-26
Online:
2021-06-25
Published:
2022-07-26
Contact:
LI Jinghang
E-mail:lijinghangn0@163.com
CLC Number:
LI Yanxiu, ZHU Enze, ZHOU Chunlei, LIU Yun, ZUO Xiangrong, LI Jinghang, CAO Quan. Relationship between vasopressin and prognosis in the patients with critical condition[J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(03): 183-187.
变量 | 倾向性匹配前 | P | 倾向性匹配后 | P | ||
---|---|---|---|---|---|---|
非血管加压素(n=55 614) | 血管加压素(n=2 171) | 非血管加压素(n=1 168) | 血管加压素(n=1 168) | |||
人口学资料 | ||||||
年龄(岁) | 64.2±57.8 | 71.2±43.8 | <0.001 | 71.2±43.8 | 70.7±41.6 | 0.721 |
年龄>60岁[n(%)] | 29 321(52.7) | 1 409(64.9) | <0.001 | 765( 65.5) | 774(66.3) | 0.720 |
男性[n(%)] | 31 018(55.8) | 1 280(59.0) | 0.002 | 691( 59.2) | 709(60.7) | 0.467 |
BMI (kg/m2) | 25.6±9.9 | 28.9±7.8 | <0.001 | 29.1±7.8 | 28.9±8.1 | 0.104 |
BMI ≥28 kg/m2[n(%)] | 9 708(37.4) | 715(47.7) | <0.001 | 577( 49.4) | 554(47.4) | 0.362 |
实验室检查 | ||||||
白细胞计数(×109/L) | 13.7±10.4 | 18.0±16.5 | <0.001 | 18.2±20.8 | 18.2±11.9 | 0.650 |
阴离子间隙(mmol/L) | 15.6±4.6 | 19.4±6.7 | <0.001 | 18.3±6.2 | 18.3±5.7 | 0.766 |
碳酸氢盐(mmol/L) | 25.1±4.4 | 22.6±5.1 | <0.001 | 23.8±4.7 | 23.0±4.8 | 0.512 |
胆红素(μmol/L) | 2.1±4.2 | 3.6±6.7 | <0.001 | 3.1±2.9 | 3.1±6.0 | 0.578 |
血糖(mmol/L) | 9.9±5.8 | 11.9±6.5 | <0.001 | 11.8±5.8 | 11.7±5.8 | 0.787 |
血红蛋白(g/ L) | 125.0±26.0 | 11.08±21.0 | <0.001 | 120.0±20.0 | 119.0±19.0 | 0.362 |
乳酸(mmol/L) | 2.8±2.2 | 5.7±4.5 | <0.001 | 4.7±4.0 | 4.8±3.6 | 0.434 |
血小板计数(×109/L) | 253.4±118.9 | 227.2±134.4 | <0.001 | 239.6±137.8 | 238.1±133.6 | 0.991 |
重症评分 | ||||||
SOFA(分) | 3.7±2.9 | 9.2±4.2 | <0.001 | 8.5±3.7 | 8.8±3.6 | 0.051 |
SIRS(分) | 2.5±1.1 | 3.3±0.8 | <0.001 | 3.3±0.8 | 3.3±0.8 | 0.238 |
并发症[n(%)] | ||||||
高血压 | 26 394(47.5) | 1 004(46.2) | <0.001 | 568(48.6) | 567(48.5) | 0.989 |
糖尿病 | 13 412(24.1) | 623(28.7) | <0.001 | 345(29.5) | 325(27.8) | 0.386 |
慢性心功能不全 | 12 996(23.4) | 878(40.4) | <0.001 | 502(43.0) | 500(42.8) | 0.972 |
慢性肺心病 | 9 612(17.3) | 409(18.8) | 0.060 | 242(20.7) | 227(19.4) | 0.471 |
慢性肾功能不全 | 7 512(13.5) | 447(20.6) | <0.001 | 242(20.7) | 239(20.5) | 0.917 |
CRRT[n(%)] | 461(0.8) | 471(21.7) | <0.001 | 192(16.4) | 214(18.3) | 0.252 |
机械通气[n(%)] | 23 238(41.8) | 1 972(90.8) | <0.001 | 1 073(91.9) | 1 105(94.6) | 0.060 |
结局指标[n(%)] | ||||||
院内死亡率 | 4 548(8.2) | 1 264(58.2) | <0.001 | 276(23.6) | 577(49.4) | <0.001 |
30 d死亡率 | 5 517(9.9) | 1 201(55.3) | <0.001 | 264(22.6) | 536(45.9) | <0.001 |
1年死亡率 | 9 696(17.4) | 1 396(64.3) | <0.001 | 381(32.6) | 649(55.6) | <0.001 |
长期死亡率 | 14 250(25.6) | 1 486(68.4) | <0.001 | 461(39.5) | 707(60.5) | <0.001 |
住院时间(d) | 10.1±12.3 | 16.0±16.4 | <0.001 | 16.0±14.9 | 18.2±16.8 | <0.001 |
住ICU时间(d) | 4.7±9.5 | 11.1±12.6 | <0.001 | 8.9±10.6 | 13.1±13.5 | <0.001 |
变量 | HR | 95% CI | P |
---|---|---|---|
年龄 | 1.004 | 1.003~1.005 | <0.001 |
BMI≥28 kg/m2 | 0.786 | 0.719~0.860 | <0.001 |
血红蛋白 | 0.919 | 0.898~0.940 | <0.001 |
乳酸 | 1.031 | 1.016~1.047 | <0.001 |
SOFA评分 | 1.056 | 1.041~1.071 | <0.001 |
慢性心功能不全 | 1.121 | 1.022~1.230 | 0.016 |
慢性肺心病 | 1.128 | 1.013~1.257 | 0.028 |
CRRT | 1.173 | 1.019~1.349 | 0.026 |
机械通气 | 1.211 | 1.078~1.361 | 0.001 |
SIRS评分 | 1.186 | 1.121~1.253 | <0.001 |
使用血管加压素 | 1.999 | 1.781~2.242 | <0.001 |
变量 | HR | 95%CI | P |
---|---|---|---|
年龄 | 1.004 | 1.003~1.005 | <0.001 |
BMI≥28 kg/m2 | 0.805 | 0.742~0.873 | <0.001 |
血红蛋白 | 0.925 | 0.907~0.945 | <0.001 |
乳酸 | 1.035 | 1.021~1.049 | <0.001 |
SOFA评分 | 1.047 | 1.033~1.061 | <0.001 |
高血压 | 0.921 | 0.850~0.998 | 0.045 |
慢性心功能不全 | 1.178 | 1.082~1.283 | <0.001 |
慢性肺心病 | 1.194 | 1.084~1.315 | <0.001 |
CRRT | 1.178 | 1.028~1.349 | 0.018 |
机械通气 | 1.176 | 1.060~1.305 | 0.002 |
SIRS评分 | 1.165 | 1.108~1.224 | <0.001 |
使用血管加压素 | 1.891 | 1.698~2.107 | <0.001 |
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