Cost of hospitalization of patients with hepatolenticular degeneration in southwest of China: data analysis during 2005-2020

doi:10.16138/j.1673-6087.2021.05.006

Abstract

Abstract:

Objective To analyze the hospitalization cost of the patients with hepatolenticular degeneration in southwest of China. Methods The data of hospitalization cost of the patients with hepatolenticular degeneration were acquired from electronic medical record system in West China Fourth Hospital from 2005 to 2020. Multiple linear regression analysis was utilized for analyzing the factors of hospitalization cost retrospectively, and covariance analysis was used for controlling the confounding factors. SPSS 20.0 (IBM) was applied for data analysis. Results A total of 346 patients with hepatolenticular degeneration were enrolled in our analysis. The year of admission, age, number of comorbidities, days of hospitalization, and complication of decompensated liver cirrhosis were the factors to influence the cost of hospitalization. After the confounding factors were adjusted, the hospitalization cost grew following the increase of comorbidity number, and complication of decompensated liver cirrhosis also led to the increase of hospitalization cost. The hospitalization cost of 2005-2006 and 2007-2008 were lower than those in the rest of years. Conclusions Hospitalization cost of the patients with hepatolenticular degeneration in southwest of China were influenced by number of comorbidities, complication of decompensated liver cirrhosis, and year to admit. It was important to reduce the occurrence of complication and decompensated liver cirrhosis, as to reduce the cost of hospitalization.

Key words: Hepatolenticular degeneration, Wilson disease, Cost, Disease burden, Comorbidity

CLC Number:

R742.4

HONG Peiwei, CONG Xue, XU Yanming. Cost of hospitalization of patients with hepatolenticular degeneration in southwest of China: data analysis during 2005-2020[J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(05): 315-318.

Figures/Tables 4

References 13

[1]	Chang IJ, Hahn SH. The genetics of Wilson disease[J]. Handb Clin Neurol, 2017, 142: 19-34.
[2]	Scheiber IF, Bruha R, Dušek P. Pathogenesis of Wilson disease[J]. Handb Clin Neurol, 2017, 142: 43-55. doi: B978-0-444-63625-6.00005-7 pmid: 28433109
[3]	Członkowska A, Litwin T, Chabik G. Wilson disease: neurologic features[J]. Handb Clin Neurol, 2017, 142: 101-119. doi: B978-0-444-63625-6.00010-0 pmid: 28433096
[4]	Boga S, Ala A, Schilsky ML. Hepatic features of Wilson disease[J]. Handb Clin Neurol, 2017, 142: 91-99.
[5]	Dziezyc K, Litwin T, Członkowska A. Other organ involvement and clinical aspects of Wilson disease[J]. Handb Clin Neurol, 2017, 142: 157-169.
[6]	Lo C, Bandmann O. Epidemiology and introduction to the clinical presentation of Wilson disease[J]. Handb Clin Neurol, 2017, 142: 7-17.
[7]	胡文彬, 韩咏竹, 薛本春, 等. 安徽省含山县肝豆状核变性的流行病学研究[J]. 中华医学杂志, 2011, 91(13):894-897.
[8]	Cheng N, Wang K, Hu W, et al. Wilson disease in the South Chinese Han population[J]. Can J Neurol Sci, 2014, 41(3): 363-367. pmid: 24718822
[9]	陈晨. 肝豆状核变性患者疾病经济负担的调查与分析[D]. 上海: 上海交通大学, 2015.
[10]	European Association for Study of Liver. EASL clinical practice guidelines: Wilson’s disease[J]. J Hepatol, 2012, 56(3): 671-685. doi: 10.1016/j.jhep.2011.11.007 URL
[11]	Saverymuttu SH, Joseph AE, Maxwell JD. Ultrasound scanning in the detection of hepatic fibrosis and steatosis[J]. Br Med J (Clin Res Ed), 1986, 292(6512): 13-15. pmid: 3080046
[12]	中华医学会肝病学分会. 肝硬化诊治指南[J]. 中华肝脏病杂志, 2019, 27(11): 846-865.
[13]	韩小敬. 基于中医临床路径的肝豆状核变性卫生经济学评价[D]. 安徽: 安徽中医药大学, 2016.

变量	β	下限	上限	P
就诊年份	0.16	260.32	590.02	<0.001
年龄	0.09	16.54	78.92	0.003
性别	-0.01	-707.42	527.52	0.775
住院前使用驱铜药物	0.00	-616.44	704.99	0.895
首发症状部位	-0.01	-173.48	127.84	0.766
合并症数量	0.13	464.09	1 258.72	<0.001
住院天数	0.82	310.01	359.95	<0.001
肝硬化失代偿	0.09	491.64	2 150.05	0.002

合并症数量	n	均数	标准误	P （vs.0)	P （vs.1)	P （vs.2)	P（vs. ≥3)
0	191	8 313.22	207.72		0.222	0.048	<0.001
1	104	8 741.79	276.12	0.222		0.259	<0.001
2	39	9 345.03	464.73	0.048	0.259		<0.001
≥3	12	12 718.24	811.39	<0.001	<0.001	<0.001
F	7.319
P	<0.001

项目	2005—2006	2007—2008	2009—2010	2011—2012	2013—2014	2015—2016	2017—2018	2019—2020
n	12	29	37	44	54	49	68	53
均数	5 445.51	6 489.49	8 650.85	8 402.34	9 275.34	8 767.06	9631.49	9 157.05
标准误	805.59	531.25	475.84	422.46	379.96	402.02	342.68	399.62
F	6.26
P	<0.001
P (vs.2005—2006)	-	0.28	0.00	0.00	0.00	0.00	0.00	0.00
P (vs.2007—2008)	0.28	-	0.00	0.00	0.00	0.00	0.00	0.00
P (vs.2009—2010)	0.00	0.00	-	0.69	0.30	0.85	0.10	0.43
P (vs.2011—2012)	0.00	0.00	0.69	-	0.12	0.53	0.03	0.20
P (vs.2013—2014)	0.00	0.00	0.30	0.12	-	0.36	0.49	0.83
P (vs.2015—2016)	0.00	0.00	0.85	0.53	0.36	-	0.10	0.49
P (vs.2017—2018)	0.00	0.00	0.10	0.03	0.49	0.10	-	0.36
P (vs.2019—2020)	0.00	0.00	0.43	0.20	0.83	0.49	0.36	-

[1]	MEI Cuiping. New Interpretation of the Death of Roderick Usher:The Result of the Declining Ecostate and Ecorole [J]. Contemporary Foreign Languages Studies, 2022, 22(5): 129-136.
[2]	WANG Fei, SHI Junli, GUO Shuzhong, et al（. Improvement of autologous costal cartilage harvest techniques in ear reconstruction　 [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2022, 18(3): 233-.
[3]	ZHOU Xiaoping, CHEN Ping. Perioperative nursing care of autologous costal cartilage transplantation for Binder syndrome　 [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2022, 18(2): 157-.
[4]	CHEN Yuyi, CHEN Lu. An Inverse Optimization Approach of Vehicle Routing Problem [J]. Journal of Shanghai Jiao Tong University, 2022, 56(1): 81-88.
[5]	SHEN Sheng, GAO Zhihui, XIN Yanlei, ZHENG Bohao, LIU Houbao, SUO Tao. Economic cost analysis of cholecystectomy based on development of specialization [J]. Journal of Surgery Concepts & Practice, 2022, 27(04): 334-339.
[6]	HUANG Mengting (黄梦婷), YI Yuhan (易雨菡), ZHANG Guanglin∗ (张光林). Service Caching and Task Oﬄoading for Mobile Edge Computing-Enabled Intelligent Connected Vehicles [J]. J Shanghai Jiaotong Univ Sci, 2021, 26(5): 670-679.
[7]	HUANG Qing, WANG Gang. Clinical phenotype and survival analysis of 106 cases of hepatolenticular degeneration [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(05): 319-324.
[8]	CHENG Ting, QIAN Haiming, GU Weimin, SHAO Zhenyi, TIAN Yuan, ZHANG Juanping, CHENG Qijian. Burden of pneumonia-associated hospitalizations: Jiading, Shanghai, 2013—2018 [J]. Journal of Internal Medicine Concepts & Practice, 2021, 16(02): 108-115.
[9]	SU Chun,ZHAO Jiabin. Optimal Design for Flexible Basic Warranty Policies Based on Usage Rate of Products [J]. Journal of Shanghai Jiaotong University, 2020, 54(11): 1182-1188.
[10]	YU Mengqi，SHI Kailong，ZHOU Xiaojun. Opportunistic Maintenance Strategy for Multi-Unit Serial Systems Based on Dual Time Window [J]. Journal of Shanghai Jiaotong University, 2020, 54(1): 69-75.
[11]	GUO Wenyu,ZHANG Xiufang,XIU Yujiao,XIA Tangbin,PAN Ershun. Integrating Strategy of Preventive Maintenance and Buffer Allocation Considering Dynamic Degradations for Manufacturing Systems [J]. Journal of Shanghai Jiaotong University, 2019, 53(9): 1107-1114.
[12]	WANG Xinliang, CAI Weifeng, QIU Lingcun, YUAN Aihua, CAO Zheng. Research on Data Association Algorithm Based on Lineofsight Distance in Photoelectric Two-dimensional Detection System [J]. Air & Space Defense, 2019, 2(4): 51-56.
[13]	CHEN Jie,XIAO Chao,SU Na,YU Wenjuan. Analysis of the Value and Clinical Significance of the Tenon-Mmortise Structure Integral Stent of Autogenous Costal Cartilage in Rhinoplasty [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(4): 245-247.
[14]	LIU Gehui (刘葛辉), LONG Xiangyu (龙翔宇), TONG Shuo (仝硕), ZHANG Rui (张瑞), CHEN Shaokuan* (陈绍宽) . Optimum Consecutive Preventive Maintenance Scheduling Model Considering Reliability [J]. Journal of Shanghai Jiao Tong University (Science), 2019, 24(4): 490-495.
[15]	DU Xingyi,OUYANG Yiye,LI Chengcheng,LIU Chunjun. Research Progress of Perforator Flaps in Breast Reconstruction [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019, 15(2): 115-118.