Journal of Internal Medicine Concepts & Practice ›› 2022, Vol. 17 ›› Issue (03): 267-272.doi: 10.16138/j.1673-6087.2022.03.019
• Review article • Previous Articles
Received:2021-12-31
Online:2022-05-30
Published:2022-08-09
CLC Number:
| 通路/系统 | 基因 | 遗传模式 | 相关疾病 |
|---|---|---|---|
| 补体系统 | C1Q | AR | SLE, AGS |
| C1R/C1S | AD | SLE | |
| C2 | AR | SLE | |
| C4 | AR | SLE | |
| C3 | AD | SLE, aHUS | |
| 凋亡通路 | DNASE1 | AD | SLE |
| DNASE2 | AR | SLE | |
| DNASE1L3 | AR | SLE | |
| TREX1 | AD/AR | SLE, AGS | |
| FAS/FASL | AD | SLE, ALPS | |
| 1型IFN信号通路 | TMEM173 | AD | SLE, SAVI, FCL |
| ACP5 | AD/AR | SLE, SPENCD | |
| SAMHD1 | AD | SLE, AGS, FCL | |
| 其他 | PRKCD | AR | SLE |
| P2RY8 | AD | SLE, APS |
| 免疫应答类型 | 通路/系统 | 基因 |
|---|---|---|
| 固有免疫 | 主要组织相容性复合物 | HLA |
| Ⅰ型IFN信号通路 | IRF | |
| STAT4 | ||
| IFIH1 | ||
| SPP1 | ||
| 免疫球蛋白的Fc受体 | FCGR | |
| NF-κB通路 | TNFAIP3 | |
| TNIP1 | ||
| UBE2L3 | ||
| ITGAM | ||
| 适应性免疫 | B细胞受体信号 | BANK1 |
| Src家族激酶：LYN、BLK、CSK | ||
| PTPN22 | ||
| LRRK1 | ||
| IKZF1 | ||
| T细胞信号 | TNFSF4 |
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