Journal of Internal Medicine Concepts & Practice ›› 2023, Vol. 18 ›› Issue (06): 451-456.doi: 10.16138/j.1673-6087.2023.06.014
• Review article • Previous Articles Next Articles
HUANG Rong1, LIU Jing’an1, ZHU Yilin1, SHI Xiaofeng2()
Received:
2022-12-08
Online:
2023-12-18
Published:
2024-03-18
CLC Number:
HUANG Rong, LIU Jing’an, ZHU Yilin, SHI Xiaofeng. The role and research progress of microRNA in acute leukemia[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(06): 451-456.
miRNA类型 | 作用结果 | 作用方式 | 作用靶基因 | 疾病类型 | 调控的细胞类型 | 信号通路 | 参考文献 |
---|---|---|---|---|---|---|---|
9 | 抑癌 | 下调 | CXCR4 | AML | Kasumi-1 | [ | |
9 | 抑癌 | 下调 | AML | HL-60 | Hippo/YAP | [ | |
93 | 促癌 | 上调 | DAB2 | AML | THP-1 | PI3K/AKT | [ |
139-5p | 抑癌 | 下调 | TSPAN3 | AML | HL-60、OCI-AML3 | PI3K/AKT | [ |
139-5p | 抑癌 | 下调 | MNT | APL | NB4 | [ | |
20a-5p | 抑癌 | 下调 | PPP6C | AML | THP-1、U937 | [ | |
451 | 抑癌 | 下调 | HMGB1 | AML | HL-60、THP-1 | [ | |
29b-3p | 抑癌 | 下调 | HUR/ELAVL1 | AML | K562、U937 | NF-κB和JAK/STAT | [ |
504-3p | 抑癌 | 下调 | MTHFD2 | AML | HL-60、THP-1 | [ | |
4792 | 抑癌 | 下调 | KINDLIN3 | AML | HL-60、Kg1a | [ | |
204 | 抑癌 | 下调 | HGF | AML | Kasumi-1、HL-60 | HGF/c-Met | [ |
182-5p | 促癌 | 上调 | BCL2L12 | AML | AML5、Kasumi-1 | [ | |
362-5p | 促癌 | 上调 | GAS7 | AML | THP-1、HL-60 | [ | |
10b | 促癌 | 上调 | HOXD10 | AML | HL-60 | [ | |
582-3p | 抑癌 | 下调 | CCNB2 | AML | THP-1 | [ | |
335-3p | 抑癌 | 下调 | EIF3E | AML | THP-1、U937 | [ | |
1306-5p | 促癌 | 上调 | PHF6 | AML | HL-60、K562 | [ | |
148a-3p | 抑癌 | 下调 | CDK6 | AML | J111、KG-1a | [ | |
1271-5p | 抑癌 | 下调 | ZIC2 | AML | AML193、OCI-AML2 | [ | |
550-1 | 抑癌 | 下调 | WWTR1 | AML | MV4-11、Kasumi-1 | [ | |
155 | 促癌 | 上调 | ZNF238 | ALL | CEM-C1、Jurkat、MOLT-3、MOLT-4 | [ | |
342 | 抑癌 | 下调 | Naa10p | AML | Kg1a、HL60 | [ | |
223 | 抑癌 | 下调 | FOXO1 | ALL | CCRF-CEM、NALM-6 | [ |
miRNA类型 | 对药物敏感性的影响 | 影响的药物 | 疾病类型 | 调控的细胞类型 | 调控的靶基因 | 信号通路 | 参考文献 |
---|---|---|---|---|---|---|---|
9 | 过表达后增强 | 柔红霉素 | AML | THP-1、KG-1、 HL60、Kasumi-1 | EIF5A2 | EIF5A2/MCL-1 | [ |
33b | 过表达后增强 | 柔红霉素 | AML | THP-1、KG-1、 Kasumi-1、HL-60 | EIF5A2 | EIF5A2/MCL-1 | [ |
15a-5p | 过表达后抑制 | 柔红霉素 | AML | K562 | ATG9A、ATG14、 GABARAPL1、SMPD1 | [ | |
15a-5p、21-5p | 过表达后抑制 | 阿糖胞甘、柔红霉素 | AML | K562、OCI-AML3 | PDCD4、ARL2、BTG2 | [ | |
199a-5p | 过表达后增强 | 多柔比星 | AML | K562 | DRAM1 | DRAM1/自噬轴 | [ |
146a、155、181a | 沉默后增强 | 泼尼松龙 | ALL | SUP-B15 | [ | ||
130a | 沉默后增强 | 多柔比星 | AML | HL-60 | [ | ||
let-7f | 过表达后增强 | 多柔比星 | AML | K562、K562/A02 | ABCC5、ABCC10 | [ | |
145 | 过表达后增强 | 地塞米松 | ALL | CEM-C1 | [ |
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