Journal of Internal Medicine Concepts & Practice ›› 2023, Vol. 18 ›› Issue (06): 377-382.doi: 10.16138/j.1673-6087.2023.06.001
• Original article • Next Articles
WEI Yihong, MA Zilin, ZHOU Duan, DENG Bing, TANG Jingyi()
Received:
2023-03-31
Online:
2023-12-18
Published:
2024-03-18
CLC Number:
WEI Yihong, MA Zilin, ZHOU Duan, DENG Bing, TANG Jingyi. Analysis of influence factors on nucleic acid negative conversion time in SARS-CoV-2 Omicron infected patients over 60 years old[J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(06): 377-382.
项目 | 病例数[n(%)] | 转阴时间 | Z/H | P |
---|---|---|---|---|
性别 | -0.146 | 0.884 | ||
男性 | 273(45.50) | 15.00(11.00~18.50) | ||
女性 | 327(54.50) | 15.00(12.00~18.00) | ||
年龄 | 10.412 | 0.015 | ||
60~<70岁 | 227(37.84) | 14.00(11.00~16.00) | ||
70~<80岁 | 170(28.33) | 15.00(12.00~19.00) | ||
80~<90岁 | 137(22.83) | 15.00(10.00~20.00) | ||
≥90岁 | 66(11.00) | 16.00(12.00~20.00) | ||
临床分型 | 25.419 | <0.001 | ||
轻型 | 438(73.00) | 15.00(12.00~19.00) | ||
普通型 | 120(20.00) | 12.00(9.25~16.00) | ||
重型/危重型 | 42(7.00) | 13.00(9.00~18.00) | ||
疫苗接种 | 3.045 | 0.385 | ||
未接种 | 443(73.84) | 15.00(12.00~19.00) | ||
1针 | 41(6.83) | 15.00(11.50~19.50) | ||
2针 | 74(12.33) | 14.50(11.75~18.00) | ||
3针 | 42(7.00) | 13.00(9.75~16.25) | ||
基础疾病 | ||||
冠心病 | 173(28.83) | 15.00(12.00~20.00) | -0.785 | 0.432 |
非冠心病 | 427(71.17) | 15.00(11.00~18.00) | ||
高血压 | 343(57.17) | 15.00(12.00~18.00) | -1.043 | 0.297 |
非高血压 | 257(42.83) | 15.00(11.00~18.00) | ||
糖尿病 | 189(31.50) | 15.00(12.00~19.00) | -1.659 | 0.097 |
非糖尿病 | 411(68.50) | 15.00(11.00~18.00) | ||
恶性肿瘤 | 115(19.17) | 16.00(12.00~20.00) | -1.991 | 0.046 |
非恶性肿瘤 | 485(80.83) | 14.00(11.00~18.00) | ||
脑梗死 | 167(27.83) | 15.00(12.00~18.25) | -0.413 | 0.679 |
非脑梗死 | 433(72.17) | 15.00(11.00~18.00) | ||
确诊至使用Paxlovid时间 | 61.265 | <0.001 | ||
≤3 d | 59(9.82) | 12.00(9.00~16.00) | ||
4~5 d | 49(8.17) | 14.00(9.50~17.50) | ||
6~7 d | 46(7.67) | 15.00(12.75~18.00) | ||
≥8 d | 118(19.67) | 18.00(14.75~22.00) | ||
未使用 | 328(54.67) | 14.00(11.00~17.00) |
项目 | 转阴时间≤14 d组(n=290) | 转阴时间>14 d组(n=310) | χ2/Z/t | P |
---|---|---|---|---|
男/女(n) | 130/160 | 143/167 | 0.102 | 0.749 |
年龄(岁) | 74.00±10.15 | 76.23±10.21 | -2.680 | 0.008 |
疫苗接种(n) | 2.530 | 0.470 | ||
未接种 | 208 | 235 | ||
1针 | 20 | 21 | ||
2针 | 37 | 37 | ||
3针 | 25 | 17 | ||
入院时实验室检验指标 | ||||
谷丙转氨酶(U/L) | 17.00(12.00~23.00) | 16.00(12.00~25.00) | -0.334 | 0.739 |
谷草转氨酶(U/L) | 24.00(18.00~31.00) | 24.00(18.00~32.00) | -0.113 | 0.910 |
肌酐(μmol/L) | 72.00(60.00~86.00) | 74.00(61.00~86.00) | -0.510 | 0.610 |
尿素(mmol/L) | 5.90(4.60~7.40) | 5.90(4.40~7.30) | -0.608 | 0.543 |
D-二聚体(mg/L) | 0.65(0.39~1.37) | 0.64(0.38~1.11) | -1.086 | 0.278 |
降钙素原(ng/L) | 37.00(0~221.20) | 33.00(0~102.00) | -0.814 | 0.415 |
白细胞介素-6(ng/L) | 6.66(3.58~22.38) | 6.67(3.36~22.49) | -0.078 | 0.938 |
NT-proBNP(ng/L) | 205.40(107.50~451.70) | 225.90(99.10~387.90) | -0.291 | 0.771 |
C反应蛋白(mg/L) | 4.13(0.59~19.33) | 3.88(0~18.48) | -0.671 | 0.502 |
白细胞总数(×109/L) | 5.60(4.45~6.91) | 5.49(4.25~7.02) | -0.363 | 0.716 |
血红蛋白(g/L) | 124.00(112.00~134.00) | 126.00(114.00~137.00) | -1.130 | 0.258 |
血小板(×109/L) | 185.00(147.00~236.00) | 185.00(147.00~226.00) | -0.360 | 0.719 |
血pH值 | 7.42(7.39~7.45) | 7.42(7.39~7.45) | -0.142 | 0.887 |
乳酸(mmol/L) | 1.60(1.30~1.90) | 1.60(1.20~2.00) | -0.011 | 0.991 |
全血剩余碱(mmol/L) | 1.70(0~2.80) | 1.50(-0.70~2.60) | -0.926 | 0.355 |
氧饱和度(%) | 96.58±3.73 | 96.67±2.31 | -0.376 | 0.707 |
核酸转阴时间(d) | 60~69岁 | 70~79岁 | 80~89岁 | ≥90岁 | 合计 |
---|---|---|---|---|---|
≤7 | 18(34.62) | 12(23.08) | 16(30.76) | 6(11.54) | 52(100.00) |
8~14 | 110(46.22) | 64(26.89) | 43(18.07) | 21(8.82) | 238(100.00) |
15~21 | 85(36.02) | 68(28.81) | 56(23.73) | 27(11.44) | 236(100.00) |
≥22 | 14(18.92) | 26(35.14) | 22(29.73) | 12(16.21) | 74(100.00) |
合计 | 227(37.84) | 170(28.33) | 137(22.83) | 66(11.00) | 600(100.00) |
项目 | 转阴≤14 d组(n=290) | 转阴>14 d组(n=310) | OR | 95%CI | P | ||
---|---|---|---|---|---|---|---|
性别 | 0.764~1.454 | 0.749 | |||||
男性 | 130 | 47.62 | 143 | 52.38 | 1.000 | ||
女性 | 160 | 48.93 | 167 | 51.07 | 1.054 | ||
年龄 | |||||||
60~69岁 | 128 | 56.39 | 99 | 43.61 | 1.000 | ||
70~79岁 | 76 | 44.71 | 94 | 55.29 | 0.625 | 0.419~0.933 | 0.022 |
80~89岁 | 59 | 43.07 | 78 | 56.93 | 0.585 | 0.381~0.898 | 0.014 |
≥90岁 | 27 | 40.91 | 39 | 59.09 | 0.535 | 0.307~0.934 | 0.028 |
疫苗接种 | 0.858~1.779 | 0.256 | |||||
未接种 | 208 | 46.95 | 235 | 53.05 | 1.000 | ||
已接种 | 82 | 52.23 | 75 | 47.77 | 1.235 | ||
基础疾病 | |||||||
冠心病 | 85 | 49.13 | 88 | 50.87 | 1.041 | 0.731~1.483 | 0.822 |
高血压 | 162 | 47.23 | 181 | 52.77 | 0.902 | 0.653~1.247 | 0.532 |
糖尿病 | 83 | 43.92 | 106 | 56.08 | 0.772 | 0.546~1.091 | 0.142 |
恶性肿瘤 | 46 | 40.00 | 69 | 60.00 | 0.646 | 0.428~0.976 | 0.038 |
脑梗死 | 77 | 46.11 | 90 | 53.89 | 0.880 | 0.615~1.258 | 0.483 |
确诊至使用Paxlovid时间 | |||||||
未使用 | 175 | 53.35 | 153 | 46.65 | 1.000 | ||
≥8 d | 29 | 24.58 | 89 | 75.42 | 0.285 | 0.178~0.457 | <0.001 |
6~7 | 18 | 39.13 | 28 | 60.87 | 0.562 | 0.299~1.056 | 0.073 |
4~5 | 28 | 57.14 | 21 | 42.86 | 1.166 | 0.636~2.137 | 0.620 |
≤3 d | 40 | 67.80 | 19 | 32.20 | 1.841 | 1.023~3.312 | 0.042 |
[1] |
Bilinski A, Thompson K, Emanuel E. COVID-19 and excess all-cause mortality in the US and 20 comparison countries, June 2021-March 2022[J]. JAMA, 2023, 329(1): 92-94.
doi: 10.1001/jama.2022.21795 URL |
[2] |
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study[J]. Lancet, 2020, 395(10223): 507-513.
doi: S0140-6736(20)30211-7 pmid: 32007143 |
[3] |
COVID-19 Forecasting Team. Past SARS-CoV-2 infection protection against re-infection: a systematic review and meta-analysis[J]. Lancet, 2023, 401(10379): 833-842.
doi: 10.1016/S0140-6736(22)02465-5 pmid: 36930674 |
[4] | 中华人民共和国国家卫生健康委员会办公厅中华人民共和国国家中医药管理局办公室. 新型冠状病毒肺炎诊疗方案(试行第九版)[J]. 中国医药, 2022, 17(4): 481-487. |
[5] |
Rosenberg ES, Dorabawila V, Easton D, et al. Covid-19 vaccine effectiveness in New York State[J]. N Engl J Med, 2022, 386(2): 116-127.
doi: 10.1056/NEJMoa2116063 URL |
[6] |
Axfors C, Ioannidis JPA. Infection fatality rate of COVID-19 in community-dwelling elderly populations[J]. Eur J Epidemiol, 2022, 37(3): 235-249.
doi: 10.1007/s10654-022-00853-w pmid: 35306604 |
[7] |
Gangneux JP, Dannaoui E, Fekkar A, et al. Fungal infections in mechanically ventilated patients with COVID-19 during the first wave: the French multicentre MYCOVID study[J]. Lancet Respir Med, 2022, 10(2): 180-190.
doi: 10.1016/S2213-2600(21)00442-2 URL |
[8] |
Ballering AV, van Zon SKR, Olde Hartman TC, et al. Persistence of somatic symptoms after COVID-19 in the Netherlands[J]. Lancet, 2022, 400(10350): 452-461.
doi: 10.1016/S0140-6736(22)01214-4 pmid: 35934007 |
[9] |
Liu YH, Wang YR, Wang QH, et al. Post-infection cognitive impairments in a cohort of elderly patients with COVID-19[J]. Mol Neurodegener, 2021, 16(1): 48.
doi: 10.1186/s13024-021-00469-w |
[10] |
Jee J, Foote MB, Lumish M, et al. Chemotherapy and COVID-19 outcomes in patients with cancer[J]. J Clin Oncol, 2020, 38(30): 3538-3546.
doi: 10.1200/JCO.20.01307 URL |
[11] |
Fillmore NR, La J, Szalat RE, et al. Prevalence and outcome of COVID-19 infection in cancer patients[J]. J Natl Cancer Inst, 2021, 113(6): 691-698.
doi: 10.1093/jnci/djaa159 URL |
[12] |
Pinato DJ, Tabernero J, Bower M, et al. Prevalence and impact of COVID-19 sequelae on treatment and survival of patients with cancer who recovered from SARS-CoV-2 infection[J]. Lancet Oncol, 2021, 22(12): 1669-1680.
doi: 10.1016/S1470-2045(21)00573-8 pmid: 34741822 |
[13] |
Najjar-Debbiny R, Gronich N, Weber G, et al. Effectiveness of Paxlovid in reducing severe coronavirus disease 2019 and mortality in high-risk patients[J]. Clin Infect Dis, 2023, 76(3): e342-e349.
doi: 10.1093/cid/ciac443 URL |
[14] |
Hammond J, Leister-Tebbe H, Gardner A, et al. Oral nirmatrelvir for high-risk, nonhospitalized adults with Covid-19[J]. N Engl J Med, 2022, 386(15): 1397-1408.
doi: 10.1056/NEJMoa2118542 URL |
[15] | Cai H, Yan J, Wang J, et al. Efficacy of Paxlovid in patients with acute kidney injury who developed COVID-19[J]. J Infect, 2022, 85(6): 702-769. |
[1] | ZHAO Yajie, HE Qing, XU Zhihong. Impact of sarcopenia on quality of life and mobility in elderly patients with chronic obstructive pulmonary disease [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(06): 383-387. |
[2] | YUAN Xiaoya, ZHANG Keke, ZHU Zhenhang, CHENG Fang, ZHAO Futao. Clinical feature of primary Sjögren’s syndrome in elderly [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(06): 400-403. |
[3] | HE Meijuan, HE Yanjie, WANG Yun, ZHU Chunxue, HUANG Hanpeng. M2-sEV inhibit endoplasmic reticulum stress to alleviate chronic intermittent hypoxic-induced H9C2 cardiomyocyte injury [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(06): 416-423. |
[4] | ZHANG Yu, WANG Zhihong, DONG Cui, KUAI Tingting, YOU Lianlian, LIU Shuxin. Comparison of ordinary calcium-containing dialysate segmented regional citrate anticoagulation hemodialysis and heparin-free hemodialysis in patients with high risk of bleeding [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(05): 322-327. |
[5] | CAI Boer, ZHU Feng, BAI Xiaojin, ZHANG Jiawen, CHEN Xiangjun. Application of case management extended care model based on WeChat platform in cirrhosis patients with esophageal and gastric varices [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(05): 344-347. |
[6] | SONG Jiani, ZHU Ying, HUANG Jia, TANG Yuming, YAO Weiyan. Mental health status of patients with esophageal symptoms and esophageal motility disorders during coronavirus pandemic [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(05): 309-315. |
[7] | BAI Tingting, LI Feika, XU Gang, JIANG Qianwen, WU Fang. A simple prediction model for risk of functional impairment in elderly [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(03): 177-182. |
[8] | ZHANG Yin, SHEN Honghua, XU Yiming, REN Lei, LI jun, WU Shunjun, LING Xiaonan. Effect of sarcopenia combined with abdominal obesity on muscle strength and physical function in hospitalized elderly [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(02): 76-82. |
[9] | LI Yanran, XU Chenying, RONG Lan, LIN Qing. Correlation of 5-year metabolic traits changes in elderly patients with chronic non-infectious diseases [J]. Journal of Internal Medicine Concepts & Practice, 2023, 18(02): 87-91. |
[10] | LI Zhen, PAN Lina, HU Jiaan, XU Zhihong. Clinical characteristics of 142 elderly patients with acute pulmonary embolism [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(05): 379-384. |
[11] | ZHANG Xiaoyan, XU Jing, QU Bin. Effect of serum vitamin D level on renal function in elderly patients with chronic kidney disease [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(04): 307-312. |
[12] | LUO Dongfeng, YOU Jianhua, LI Xiaoyang, LI Junmin, ZHANG Yunxiang. Study on the efficacy and safety of different induction therapies in newly diagnosed elderly patients with acute myeloid leukemia and intolerance of intensive chemotherapy [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(03): 220-226. |
[13] | SUN Chao, HUANG Jia, ZHU Ying, YAO Weiyan, TANG Yuming. Correlation between asymptomatic erosive esophagitis and colorectal polyps [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(03): 233-237. |
[14] | LI Feika, YANG Wenli, JIANG Qianwen, FANG Fang, BAI Tingting, XU Gang, WU Fang, HE Qing. Development of preliminary scales for elderly sarcopenia based on Delphi method [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(03): 238-242. |
[15] | LIANG Jing, LIANG Xiaohong, XIANG Xiaogang, ZHOU Zengding, WANG Zhengting, GUO Ying, CHEN Jiayi, ZHAO Xiaojie, CAO Weiwei, JING Feng. Using ImageJ software to evaluate the effect of the seven-step handwashing method at home for citizens during COVID-19 pandemic [J]. Journal of Internal Medicine Concepts & Practice, 2022, 17(02): 156-158. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||