Research progress of coagulation factor XIII and venous thromboembolism

doi:10.16138/j.1673-6087.2024.05.09

Abstract

Abstract:

Venous thromboembolism (VTE) is the third most common cardiovascular disease worldwide, and its incidence continues to rise. Coagulation factor XIII (FXIII, factor XIII), also known as fibrin stabilization factor, is involved in multiple stages of the clotting cascade. Recent studies have found that FXIII is a key factor in determining the volume, structure and stability of venous thrombosis, and may play an important role in the formation, shedding or dissolution of deep venous thrombosis. This paper reviews the research progress of FXIII and VTE, in order to provide new ideas for the prevention, diagnosis and treatment of VTE.

Key words: Venous thromboembolism, Deep vein thrombosis, Pulmonary embolism, Coagulation factor XIII

CLC Number:

R543.2

XIE Xuemeng, HU Ling. Research progress of coagulation factor XIII and venous thromboembolism[J]. Journal of Internal Medicine Concepts & Practice, 2024, 19(05): 333-336.

References 34

[1]	Khan F, Tritschler T, Kahn SR, et al. Venous thromboembolism[J]. Lancet, 2021, 398(10294):64-77. doi: 10.1016/S0140-6736(20)32658-1 pmid: 33984268
[2]	Lutsey PL, Zakai NA. Epidemiology and prevention of venous thromboembolism[J]. Nat Rev Cardiol, 2023, 20(4):248-262.
[3]	Law Y, Chan YC, Cheng SWK. Epidemiological updates of venous thromboembolism in a Chinese population[J]. Asian J Surg, 2018, 41(2):176-182. doi: S1015-9584(16)30306-2 pmid: 28012866
[4]	Javed H, Singh S, Ramaraje Urs SU, et al. Genetic landscape in coagulation factor XIII associated defects - Advances in coagulation and beyond[J]. Blood Rev, 2023, 59:101032.
[5]	Al-Horani RA, Kar S. Factor XIIIa inhibitors as potential novel drugs for venous thromboembolism[J]. Eur J Med Chem, 2020, 200:112442.
[6]	Chernysh IN, Nagaswami C, Kosolapova S, et al. The distinctive structure and composition of arterial and venous thrombi and pulmonary emboli[J]. Sci Rep, 2020, 10(1):5112. doi: 10.1038/s41598-020-59526-x pmid: 32198356
[7]	Mitchell JL, Little G, Bye AP, et al. Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability[J]. Res Pract Thromb Haemost, 2023, 7(5):100200.
[8]	Kattula S, Byrnes JR, Martin SM, et al. Factor XIII in plasma, but not in platelets, mediates red blood cell retention in clots and venous thrombus size in mice[J]. Blood Adv, 2018, 2(1):25-35. doi: 10.1182/bloodadvances.2017011890 pmid: 29344582
[9]	Duval C, Baranauskas A, Feller T, et al. Elimination of fibrin γ-chain cross-linking by FXIIIa increases pulmonary embolism arising from murine inferior vena cava thrombi[J]. Proc Natl Acad Sci U S A, 2021, 118(27):e2103226118.
[10]	Kattula S, Sang Y, de Ridder G, et al. Novel venous thromboembolism mouse model to evaluate the role of complete and partial factor XIII deficiency in pulmonary embolism risk[J]. J Thromb Haemost, 2021, 19(12):2997-3007. doi: 10.1111/jth.15510 pmid: 34431201
[11]	Shaya SA, Gani DM, Weitz JI, et al. Factor XIII prevents pulmonary emboli in mice by stabilizing deep vein thrombi[J]. Thromb Haemost, 2019, 119(6):992-999.
[12]	Ząbczyk M, Natorska J, Undas A. Factor XIII and fibrin clot properties in acute venous thromboembolism[J]. Int J Mol Sci, 2021, 22(4):1607.
[13]	Kool RO, Kohler HP, Coutinho JM, et al. Coagulation factor XIII-A subunit and activation peptide levels in individuals with established symptomatic acute deep vein thrombosis[J]. Thromb Res, 2017, 159:96-99. doi: S0049-3848(17)30525-X pmid: 29054013
[14]	Tang N, Sun Z, Li D, et al. Combined measurement of factor XIII and D-dimer is helpful for differential diagnosis in patients with suspected pulmonary embolism[J]. Clin Chem Lab Med, 2017, 55(12):1948-1953. doi: 10.1515/cclm-2017-0072 pmid: 28412719
[15]	Kucher N, Schroeder V, Kohler HP. Role of blood coagulation factor XIII in patients with acute pulmonary embolism. Correlation of factor XIII antigen levels with pulmonary occlusion rate, fibrinogen, D-dimer, and clot firmness[J]. Thromb Haemost, 2003, 90(3):434-438.
[16]	Bronić A, Ferenčak G, Bernat R, et al. Association of fibrinogen and plasmin inhibitor, but not coagulation factor XIII gene polymorphisms with coronary artery disease[J]. J Med Biochem, 2021, 40(2):138-149. doi: 10.5937/jomb0-26839 pmid: 33776563
[17]	Wolberg AS. Fibrinogen and fibrin: synthesis, structure, and function in health and disease[J]. J Thromb Haemost, 2023, 21(11):3005-3015. doi: 10.1016/j.jtha.2023.08.014 pmid: 37625698
[18]	Wolberg AS, Sang Y. Fibrinogen and factor XIII in venous thrombosis and thrombus stability[J]. Arterioscler Thromb Vasc Biol, 2022, 42(8):931-941. doi: 10.1161/ATVBAHA.122.317164 pmid: 35652333
[19]	Muszbek L, Bagoly Z, Bereczky Z, et al. The involvement of blood coagulation factor XIII in fibrinolysis and thrombosis[J]. Cardiovasc Hematol Agents Med Chem, 2008, 6(3):190-205. doi: 10.2174/187152508784871990 pmid: 18673233
[20]	Meißner L, Schürmann P, Dörk T, et al. Genetic association study of fatal pulmonary embolism[J]. Int J Legal Med, 2021, 135(1):143-151. doi: 10.1007/s00414-020-02441-7 pmid: 33128086
[21]	Kupis RW, Goldman-Mazur S, Polak M, et al. Faster fibrin clot degradation characterizes patients with central pulmonary embolism at a low risk of recurrent peripheral embolism[J]. Sci Rep, 2019, 9(1):72. doi: 10.1038/s41598-018-37114-4 pmid: 30635605
[22]	Sawai Y, Yamanaka Y, Nomura S. Clinical significance of factor XIII activity and monocyte-derived microparticles in cancer patients[J]. Vasc Health Risk Manag, 2020, 16:103-110. doi: 10.2147/VHRM.S240500 pmid: 32280233
[23]	Weeks KS, Herbach E, McDonald M, et al. Meta-analysis of VTE risk: ovarian cancer patients by stage, histology, cytoreduction, and ascites at diagnosis[J]. Obstet Gynecol Int, 2020, 2020:2374716.
[24]	Zeerleder S, Schroeder V, Lämmle B, et al. Factor XIII in severe sepsis and septic shock[J]. Thromb Res, 2007, 119(3):311-318. pmid: 16574200
[25]	Al-Nasser B. Influence of tobacco smoking on perioperative risk of venous thromboembolism[J]. Turk J Anaesthesiol Reanim, 2020, 48(1):11-16. doi: 10.5152/TJAR.2019.08683 pmid: 32076674
[26]	Rijken DC, Abdul S, Malfliet JJ, et al. Compaction of fibrin clots reveals the antifibrinolytic effect of factor[J]. J Thromb Haemost, 2016, 14(7):1453-1461. doi: 10.1111/jth.13354 pmid: 27148673
[27]	Hur WS, Warner H, Machan L, et al. Coagulation factor XIII-A and activated FXIII-A decrease in some deep vein thrombosis patients following catheter-directed thrombolysis[J]. Blood Coagul Fibrinolysis, 2019, 30(4):176-180.
[28]	Liu Y, Crossen J, Stalker TJ, et al. Fluorescent peptide for detecting factor XIIIa activity and fibrin in whole blood clots forming under flow[J]. Res Pract Thromb Haemost, 2023, 8(1):102291.
[29]	Wang Y, Xu X, Zhao X, et al. Functionalized polymeric hybrid micelles as an efficient nanotheranostic agent for thrombus imaging and thrombolysis[J]. Acta Biomater, 2021, 122:278-290. doi: 10.1016/j.actbio.2020.10.015 pmid: 33359293
[30]	Andrews JPM, Portal C, Walton T, et al. Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer[J]. Eur Heart J Cardiovasc Imaging, 2020, 21(6):673-682. doi: 10.1093/ehjci/jez207 pmid: 31408105
[31]	Daneshpour N, Collighan R, Perrie Y, et al. Indwelling catheters and medical implants with FXIIIa inhibitors: a novel approach to the treatment of catheter and medical device-related infections[J]. Eur J Pharm Biopharm, 2013, 83(1):106-113. doi: 10.1016/j.ejpb.2012.09.005 pmid: 23022540
[32]	Macor P, Durigutto P, Argenziano M, et al. Plasminogen activator-coated nanobubbles targeting cellbound β2-glycoprotein Ⅰ as a novel thrombus-specific thrombolytic strategy[J]. Haematologica, 2023, 108(7):1861-1872.
[33]	Marin E, Kornilov DA, Bukhdruker SS, et al. Structural insights into thrombolytic activity of destabilase from medicinal leech[J]. Sci Rep, 2023, 13(1):6641. doi: 10.1038/s41598-023-32459-x pmid: 37095116
[34]	Quintal Martínez JP, Segura Campos MR. Bioactive compounds and functional foods as coadjuvant therapy for thrombosis[J]. Food Funct, 2023, 14(2):653-674. doi: 10.1039/d2fo03171j pmid: 36601778