Journal of Internal Medicine Concepts & Practice ›› 2025, Vol. 20 ›› Issue (01): 76-80.doi: 10.16138/j.1673-6087.2025.01.16

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Research progress of polydatin in treatment of digestive system diseases

WU Chao1a, ZHUANG Lei1b(), MA Junjun1a, HE Zirui1a, SUN Yongshun2()   

  1. 1a. Department of General Surgery, Shanghai Clinical Center for Minimally Invasive Surgery; b. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
    2. Department of Gastroenterology,Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 200071,China
  • Received:2024-10-29 Online:2025-02-28 Published:2025-04-30
  • Contact: ZHUANG Lei, SUN Yongshun E-mail:zl11211@rjh.com.cn;13764403043@163.com

Abstract:

Polydatin is the main active ingredient extracted from the traditional Chinese herbal medicine Polygonum cuspidatum, which has multiple pharmacological effects such as anti-inflammation, antioxidant and apoptosis regulation. Its application in the treatment of liver disease, inflammatory bowel disease and other digestive system diseases has gradually attracted attention. This article reviews therapeutic progress of polydatin in benign and malignant diseases of the digestive system (liver, gallbladder, pancreas and gastrointestinal tract), analyzes the potential mechanism of polydatin in the treatment of digestive disorders. We hope to provide new ideas for in-depth research on application of polydatin in digestive disorders.

Key words: Polydatin, Digestive system, Polygonum cuspidatum

CLC Number: