Explore mechanism and progress of kidney-tonifying method on middle-aged and elderly essential hypertension based on traditional Chinese medicine theory of “tonifying kidney and resisting aging”

doi:10.16138/j.1673-6087.2025.01.14

Abstract

Abstract:

Hypertension is a common disease and the most important risk factor for cardiovascular diseases (CVD). Lowering blood pressure effectively and stably is the key to reduce CVD. Unlike single-mechanism drugs, traditional Chinese medicine (TCM) has the synergistic effect of multi-target and multi-mechanism on the treatment of essential hypertension. According to the theory of TCM, kidney essence deficiency and liver-yang hyperactivity are the characteristics and pathogenesis of hypertension. The method of tonifying kidney has a long history in treating hypertension, and it embodies the basic concept ‘treat disease, cure must seek the root cause’ in TCM. The article reviews the clinical studies on various kidney-tonifying methods, explores the mechanisms and summarizes the research progress, to provide reference for the clinical treatment of hypertension with the combination of traditional Chinese and Western medicine.

Key words: Tonifying kidney therapy, Middle-aged and elderly, Hypertension, Traditional Chinese medicine therapy

CLC Number:

R544.1
R25

XU Tingyan, ZHANG Jin, GU Yun. Explore mechanism and progress of kidney-tonifying method on middle-aged and elderly essential hypertension based on traditional Chinese medicine theory of “tonifying kidney and resisting aging”[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(01): 67-70.

References 29

[1]	吴兆苏, 霍勇, 王文, 等. 中国高血压患者教育指南[J]. 中国医学前沿杂志(电子版), 2014, 6(3):78-110.
[2]	Fan J, Watanabe T. Atherosclerosis: known and unknown[J]. Pathol Int, 2022, 72(3):151-160. doi: 10.1111/pin.13202 pmid: 35076127
[3]	马勇博, 于杰, 王晓杰, 等. 槲寄生在高血压病应用研究进展[J]. 辽宁中医药大学学报, 2024, 26(1):129-132.
[4]	蔡智刚, 唐新征, 张毅. 补中益气汤治疗气虚型高血压病临床观察[J]. 辽宁中医药大学学报, 2013, 15(8):223-224.
[5]	滕英华, 谢睿, 史先知. 补肾活血汤对老年肾虚血瘀型高血压患者血压变异性和生活质量的影响[J]. 中国实验方剂学杂志, 2016, 22(20):173-177.
[6]	陈翊. 补肾益心方联合耳穴压豆治疗难治性高血压的临床观察[J]. 内蒙古中医药, 2022, 41(7):104-106.
[7]	历佳. 补肾活血汤对老年高血压左室肥厚的影响[J]. 中国医药指南, 2020, 18(2):172-173.
[8]	任小娟, 任美娜. 自拟补肾和脉方联合硝苯地平片治疗老年高血压合并左室肥厚的临床观察[J]. 云南中医中药杂志, 2014, 35(6):43-45.
[9]	尹佳. 平肝补肾活血法改善高血压左房功能的临床研究[D]. 济南: 山东中医药大学, 2012.
[10]	顾耘. 软脉煎治疗颈动脉粥样硬化的临床研究[J]. 辽宁中医杂志, 2004, 31(8):634-636.
[11]	孙国珺, 王臻楠, 顾耘, 等. 软脉煎联合辛伐他汀、阿司匹林对肾精亏虚型颈动脉粥样硬化患者baPWV、ABI的影响[J]. 河南中医, 2018, 38(11):1673-1677.
[12]	赵黎, 王维维. 自拟补肾降压方对高血压患者血清炎性因子、肱-踝脉搏波传导速度及颈动脉内膜中层厚度的影响[J]. 现代中西医结合杂志, 2016, 25(28):3082-3084.
[13]	王辞晓, 赵良斌, 黄佑群. 益气活血补肾方联合厄贝沙坦对高血压性肾损害患者肾功能的保护作用[J]. 陕西中医, 2021, 42(6):735-738.
[14]	何丽杰, 车启富. 益气活血补肾方联合硝苯地平对高血压肾病所致肾衰患者尿蛋白、Scr、BUN及临床疗效的影响[J]. 中国医学创新, 2018, 15(4):130-133.
[15]	曾悦, 刘峻, 周鸿飞. 补肾涤痰化瘀汤治疗原发性高血压临床观察[J]. 光明中医, 2019, 34(17):2637-2640.
[16]	王硕, 李明, 李志栋, 等. 滋阴补肾填精益髓法对老年高血压患者血液流变学、血管内皮功能及动脉弹性功能的影响[J]. 现代中西医结合杂志, 2022, 31(12):1670-1673.
[17]	文秀莲, 李洁. 补肾活血汤对老年单纯收缩期高血压(肾虚血瘀证)患者血管内皮功能的影响[J]. 中国中医急症, 2014, 23(2):248-250.
[18]	杨波, 寇媛. 清眩补肾汤治疗原发性高血压对患者血压水平及肾素-血管紧张素-醛固酮系统的影响[J]. 山西医药杂志, 2021, 50(12):1972-1975.
[19]	余永林. 补肾降压方治疗原发性高血压的可行性及安全性研究[J]. 中外医疗, 2015(25):180-181.
[20]	肖沐紫, 王思齐, 贾壮壮, 等. 基于网络药理学及实验验证探讨补肾定眩汤治疗高血压的作用机制[J]. 中国疗养医学, 2024, 33(2):25-31. doi: 10.13517/j.cnki.ccm.2024.02.005
[21]	杨晓忱, 张云, 刘咏梅, 等. 基于网络药理学探讨补肾降压方治疗高血压的作用机制[J]. 中西医结合心脑血管病杂志, 2021, 19(2):197-205.
[22]	徐梦月, 王强, 白娟, 等. 肠道菌群代谢物与高血压关系的研究进展[J]. 重庆医学, 2023, 52(13):2040-2045.
[23]	Yang T, Magee KL, Colon-Perez LM, et al. Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats[J]. Acta Physiol (Oxf), 2019, 226(2):e13256.
[24]	Zubcevic J, Richards EM, Yang T, et al. Impaired autonomic nervous system-microbiome circuit in hypertension[J]. Circ Res, 2019, 125(1):104-116. doi: 10.1161/CIRCRESAHA.119.313965 pmid: 31219753
[25]	张李慧. 补肾和脉颗粒对高血压的临床疗效观察及肠道菌群影晌的研究[D]. 济南: 山东中医药大学, 2021.
[26]	Zhou JJ, Ma HJ, Shao JY, et al. Impaired hypothalamic regulation of sympathetic outflow in primary hypertension[J]. Neurosci Bull, 2019, 35(1):124-132.
[27]	Geraldes V, Laranjo S, Rocha I. Hypothalamic ion channels in hypertension[J]. Curr Hypertens Rep, 2018, 20(2):14. doi: 10.1007/s11906-018-0814-x pmid: 29480403
[28]	甄晓敏, 王培伟, 崔金刚, 等. 清肝益肾祛风方干预血管紧张素Ⅱ诱导的小鼠高血压及神经炎症的作用研究[J]. 世界科学技术-中医药现代化, 2021, 23(2):462-467.
[29]	史琳, 杨传华. 补肾和脉方对老年自发性高血压大鼠下丘脑蛋白质组学的影响[J]. 中国中医急症, 2024, 33(2):209-214.