Advances in pathogenesis and treatment of chronic obstructive pulmonary disease complicated with sarcopenia

doi:10.16138/j.1673-6087.2025.05.13

Abstract

Abstract:

Chronic obstructive pulmonary disease (COPD) is one of the most common chronic diseases of the respiratory tract, with a high mortality and disability rate. Sarcopenia is an important extrapulmonary manifestation in COPD patients, and its incidence rate is not low. The pathogenesis of COPD complicated with sarcopenia involves oxidative stress, systemic inflammatory response, autophagy, malnutrition and decreased physical activity, etc. Current research has shown that exercise intervention, nutritional support, and medication treatment can improve patients’ muscle strength and physical mobility, thereby enhancing patient prognosis. This article comprehensively reviews the pathogenesis and treatment of COPD complicated with sarcopenia, aiming to provide a valuable reference for disease research, diagnosis and treatment.

Key words: Chronic obstructive pulmonary disease, Sarcopenia, Pathogenesis, Epidemiology

CLC Number:

R563

WANG Yi, HUANG Hui. Advances in pathogenesis and treatment of chronic obstructive pulmonary disease complicated with sarcopenia[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(05): 415-419.

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