Research advances on pyroptosis in pulmonary diseases

doi:10.16138/j.1673-6087.2025.05.14

Abstract

Abstract:

Pyroptosis is a new type of programmed cell death discovered and confirmed in recent years. It is accompanied by changes in intracellular and extracellular osmotic pressure, cell rupture, and the leakage of pro-inflammatory substances, thereby leading to severe inflammatory reactions. In recent years, increased evidence has shown that pyroptosis is closely related to lung diseases, such as lung cancer, bronchial asthma, chronic obstructive pulmonary disease, lung injury, pulmonary arterial hypertension, etc. This article aims to review the role of pyroptosis and its pathophysiological relationship with lung diseases.

Key words: Pyroptosis, Lung cancer, Bronchial asthma, Chronic obstructive pulmonary disease

CLC Number:

R563.5

LI Xianmei, LI Min, YANG Zhenning, LI Wei. Research advances on pyroptosis in pulmonary diseases[J]. Journal of Internal Medicine Concepts & Practice, 2025, 20(05): 420-425.

Figures/Tables 1

References 45

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