Crk在胃癌中的表达及其临床意义

doi:10.16139/j.1007-9610.2018.03.015

外科理论与实践 ›› 2018, Vol. 23 ›› Issue (03): 258-262.doi: 10.16139/j.1007-9610.2018.03.015

Crk在胃癌中的表达及其临床意义

冯润华^a,b,c, 毕任达^a, 陆晟^a, 袁菲^d, 许海敏^d, 刘炳亚^b,c, 燕敏^a, 李琛^a,b,c, 朱正纲^a,b,c

上海交通大学医学院附属瑞金医院 a.外科, b.上海消化外科研究所,c.上海市胃肿瘤重点实验室,d.病理科,上海 200025

收稿日期:2018-02-28 发布日期:2020-07-25
通讯作者: 朱正纲,E-mail: drzhenggangzhu@hotmail.com
基金资助:
上海交通大学“医工交叉研究基金”（YG2016 MS65）; 上海市浦江人才计划（17PJ1406000）

Clinical significance of Crk expression in gastric cancer

FENG Runhua^a,b,c, SAH K. Birendra^a, LU Sheng^a, YUAN Fei^d, XU Haimin^d, LIU Bingya^b,c, YAN Min^a, LI Chen^a,b,c, ZHU Zhenggang^a,b,c

a. Department of Surgery, b. Shanghai Institute of Digestive Surgery, c. Shanghai Key Laboratory of Gastric Neoplasms, d. Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received:2018-02-28 Published:2020-07-25

摘要/Abstract

摘要： 目的: 探讨接头蛋白Crk在胃癌组织中的表达及其与胃癌临床病理因素及预后的关系。方法: 采用免疫组织化学方法检测368例胃癌病人肿瘤组织和配对癌旁组织Crk蛋白表达水平,分析其表达与临床病理因素及预后之间的关系。结果: 与癌旁组织相比,胃癌组织中Crk蛋白表达水平明显升高（P<0.05）。其表达水平与肿瘤大小（P<0.05）、浸润深度（P<0.05）、淋巴结转移（P<0.05）、TNM 分期（P<0.05）密切相关。Crk蛋白表达水平越高,病人预后越差（P<0.05）。多因素分析表明,Crk蛋白是影响胃癌病人预后的独立危险因素。结论: Crk蛋白在胃癌的发生、发展中起重要作用,可作为预测胃癌预后的分子标志物。

关键词: 接头蛋白Crk, 胃癌, 免疫组织化学, 预后

Abstract: Objective: To evaluate the expression of adaptor protein Crk in gastric cancer and the associations with clinicopathological characteristics and prognosis of gastric cancer. Methods: The expression of Crk protein of matched tumor and adjacent tissues in 368 patients with gastric cancer was analyzed by immunohistochemistry. The relation of Crk protein expression with clinicopathological characteristics and clinical outcome was evaluated. Results: Compared with adjacent non-tumor tissues, Crk protein was significantly up-regulated in tumor tissues (P<0.05). An elevated Crk protein expression statistically related with aggressive clinicopathological characteristics significantly including larger tumor size (P<0.05), deeper local invasion (P<0.05), more lymph node metastasis (P<0.05) and advanced TNM stage (P<0.05). Gastric cancer patients with higher expression of Crk protein had poorer prognosis (P<0.05). Multivariate analysis showed that higher level of Crk protein was an independent unfavorable prognostic factor of gastric cancer. Conclusions: Crk protein may be associated with tumor progression in gastric cancer and may predict unfavorable prognosis of gastric cancer as a novel molecular marker.

Key words: Adaptor protein Crk, Gastric cancer, Immunohistochemistry, Prognosis

中图分类号:

R735.2

冯润华, 毕任达, 陆晟, 袁菲, 许海敏, 刘炳亚, 燕敏, 李琛, 朱正纲. Crk在胃癌中的表达及其临床意义[J]. 外科理论与实践, 2018, 23(03): 258-262.

FENG Runhua, SAH K. Birendra, LU Sheng, YUAN Fei, XU Haimin, LIU Bingya, YAN Min, LI Chen, ZHU Zhenggang. Clinical significance of Crk expression in gastric cancer[J]. Journal of Surgery Concepts & Practice, 2018, 23(03): 258-262.

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Crk在胃癌中的表达及其临床意义

Clinical significance of Crk expression in gastric cancer

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