Macrofollicular variant of papillary thyroid carcinoma: a report of 3 cases

doi:10.16139/j.1007-9610.2018.01.013

Abstract

Abstract: Objective To investigate the clinicopathologic features of macrofollicular variant of papillary thyroid carcinoma (MFPTC). Methods Three cases with MFPTC were analyzed retrospectively for the clinical data, pathological morphology and the results by immunohistochemical detection. Results The ultrasonic examination showed MFPTC mostly as irregular strong hyperechoic nodules with abundant blood flow. Under the microscope, huge follicles could be observed and there was rich of colloid in the cavity of follicles. The nucleus of the follicular epithelium was extruded into a cubic or flattened form. MFPTC could be diagnosed similar to the other PTC by immunohistochemistry. The diffusive or partial distribution of positive expression of CK19, galectin-3, and HBME-1 was shown in the epithelium of MFPEC. Conclusions MFPTC was inclined to be miss-diagnosed in the clinics and pathology. With clinical data and the histomorphologic feature combined with immunohistochemical examination, MFPTC could be confirmed pathologically.

Key words: Thyroid tumor, Macrofollicular variant, Papillary carcinoma, Immunohistochemistry

CLC Number:

R736.1

YU Qichun, YIN Jianguang, SHANG Yanhong, QIU Weihua, TAN Jian. Macrofollicular variant of papillary thyroid carcinoma: a report of 3 cases[J]. Journal of Surgery Concepts & Practice, 2018, 23(01): 57-61.

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