Endolymphatic sac tumor: Clinicopathological features and review of literature

doi:10.16150/j.1671-2870.2018.06.016

Abstract

Abstract: Objective: To study the clinnicopathological features and differential diagnosis of endolymphatic sac tumorfor improving the understanding of this rare tumor. Methods: Tumor specimen from a case of endolymphatic sac tumor was observed under light microscope. Immunohistochemistry examination was performed and relevant literatures were reviewed. Results: Histopathologic examination presented a papillary-glandular pattern, and was covered by a single layer columnar epithelium cells containing clear cytoplasm. There were minimal cellular atypia. The stroma was rich in large number of proliferative fibrous connective tissue. Immunohistochemically,the tumor cells were diffusely positive for AE1/AE3, EMA, vimentin, focally positive for GFAP, S-100, andnegative for Syn, CgA, NSE, TTF-1, TG. The proliferating index Ki-67 was about 1%. Conclusions: Endolymphatic sac tumor is rare, and lacks specific clinical manifestations. The pathological diagnosis depends on morphologic characteristics in paraffin-embedded tissue section and immunohistochemical staining. Whole intact tumor resection is the most effective treatment ofendolymphatic sac tumor.

Key words: Endolymphatic sac tumor, Pathology, Immunohistochemistry

CLC Number:

R446.8

HAN Dongyan, FU Huijun, HE Yanyan, XI Hao, WEI Qing. Endolymphatic sac tumor: Clinicopathological features and review of literature[J]. Journal of Diagnostics Concepts & Practice, 2018, 17(06): 711-714.

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