Abstract: Objective To review the experience of diagnosis and treatment of focal nodular hyperplasia (FNH) in our department for the management of FNH represents a challenge. Methods Twenty-two cases with FNH from October 2010 to January 2017 were studied retrospectively. All patients were diagnosed as FNH by postoperative pathological assessment. Results Twelve male cases and 10 female cases with FNH were recruited with sex ratio 1.2∶ 1.0 and mean age (32.50± 8.38)(18-50) years. Three cases manifested clinical symptoms with 3 cases of abdominal pain and one case of high CA-724 level. The others had no any symptoms. Seventeen cases were diagnosed as FNH by imaging. All cases received surgical therapy with operating time (142.72± 54.81) (50-300) min, operative blood loss (397.27± 466.95) (50-1 700) mL and hospital stay(7.90± 2.86) (4-15) days, There was no both severe morbidity and mortality peri-operatively and no recurrent case was found during the period of follow-up from 11 to 75 months. Conclusions FNH is a rare benign proliferative lesion of liver with rare clinical symptoms and characterized by central scar. Combination of several imaging modalities would be valuable to the diagnosis. For the patients with symptomatic FNH, combined with hepatitis and cirrhosis or difficult to distinguished from hepatic cancer or hepatic adenoma, surgical resection should be considered and the prognosis is better.

Key words: Hepatic tumors, Focal nodular hyperplasia (FNH), Diagnosis, Therapy