Long-term outcome of total parathyroidectomy with autotransplantation in treatment of renal secondary hyperparathyroidism

doi:10.16139/j.1007-9610.2018.06.012

Abstract

Abstract: Objective To explore the long-term outcome of total parathyroidectomy with forearm autotransplantation (TPTX+AT) in the treatment of patients with secondary hyperparathyroidism (SHPT) of renal disease. Methods A total of 124 patients with SHPT were subjected to TPTX+AT from January 1999 to November 2017 and were analyzed. The clinical data including symptom relief, calcium, phosphate and intact parathyroid hormone (iPTH) in serum before and after the surgery were collected. Recurrence rate, persistent hypoparathyroidism and mortality rate were analyzed. Results After operation, symptoms relieved significantly. Calcium, phosphate and iPTH in serum decreased significantly 1 month postoperative when compared those preoperative, and could be maintained well for a long period. It was shown that 10 patients(8.06%) had recurrence, 7 patients(5.64%) had persistent hypoparathyroidism and 19 patients (15.32%) died after follow-up until to May 2018. Conclusions TPTX+AT could be performed to treat patients with SHPT that relieves symptoms effectively and improves calcium and phosphorus metabolism for a long period. Recurrence rate, persistent hypoparathyroidism and mortality might be maintained at a lower level.

Key words: Total parathyroidectomy with forearm autotransplantation, Chronic kidney diseases, Secondary hyperparathyroidism

CLC Number:

R653

WANG Hongying, HUANG Junwen, ZOU Qiang, CHEN Jing, ZHANG Minmin, ZHANG Weichen, LAO Zhengyin. Long-term outcome of total parathyroidectomy with autotransplantation in treatment of renal secondary hyperparathyroidism[J]. Journal of Surgery Concepts & Practice, 2018, 23(06): 523-527.

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