Abstract: Objective To compare the results after purge parathyroidectomy (PPTX) and traditional approaches performed for secondary hyperparathyroidism (SHPT). Methods A total of 49 patients with SHPT who underwent parathyroidectomy from January 2010 to November 2017 were retrospectively analyzed. We compared outcomes between PPTX group and traditional parathyroidectomy group including total parathyroidectomy and total parathyroidectomy with autotransplantation. Results There was no difference in the rate of persistent or recurrent SHPT between 2 groups during follow-up (P>0.05). Analysis of the patients with successful surgery revealed that patients in PPTX group had a lower level of intact parathyroid hormone (iPTH) at 6 months postoperatively compared with that in traditional parathyroidectomy group (P=0.013). No significant difference was found between 2 groups in the rate of transient or persistent lower iPTH (P>0.05). Patients in PPTX group required more calcium supplementation(P=0.003), while no difference was present in the extent of hypocalcemia between 2 groups (P>0.05). Conclusions PPTX would be more effective in lowering iPTH. However, the patients need more calcium supplementation to prevent hypocalcemia after PPTX.

Key words: Purge parathyroidectomy, Secondary hyperparathyroidism, Parathyroid hormone, Recurrence