Research on microgravity which affects thyroid tumor

doi:10.16139/j.1007-9610.2021.02.018

Abstract

CLC Number:

R736.1

CHEN Xuemei, CHEN Yuanyang, ZHOU Quanhong. Research on microgravity which affects thyroid tumor[J]. Journal of Surgery Concepts & Practice, 2021, 26(02): 179-182.

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References 39

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参考文献	生物学表型	细胞系	结果
张倍宁^[9]	增殖能力（抑制）	FRTL-5	细胞周期蛋白：Cyclin D1、Cyclin B1↓
Warnke等^[13]	细胞外基质和细胞骨架	Nthy-ori3-1	TUBB、ACTB、PFN-1、PKC、ERK1、ERK2、Casp9、OSP↑, VEGF↓
Grimm等^[18]	细胞活性（抑制）和细胞凋亡（促进）	ML-1	促进凋亡：PARP、p53和Bax↑,抑制凋亡：BCL-2↓
Riwaldt等^[21]	细胞外基质和细胞骨架	UCLA RO82-W-1	VEGFD、VEGFA、MSN、MMP3、CAV1、ACTB、ACTA2、KRT8、TUBB↑,MMP9、CTGF、MCP1↓
Kopp等^[22]	细胞外基质和细胞骨架	FTC-133	ACTB、TUBB、EGF、CTGF、VEGF、ERK1、ERK2↑, CAV1、CAV2、CTGF、PRKCA、MMP3↓
Ulbrich等^[23]	细胞外基质和细胞骨架	ML-1	PXN、VCL、PTK2、F-actin、ACTB、KRT80、OPN、FN↑,COL4A5、LIMA1、MTSS1↓

参考文献	细胞系	干预条件	信号通路
Melnik等^[11]	FTC-133	RPM	地塞米松可通过Wnt/β-catenin信号通路影响模拟微重力下甲状腺癌细胞球体的形成
Zhao等^[24]	BL6-10	FRC	FAK/RhoA调节的mTORC1途径抑制细胞增殖/转移
Deng等^[25]	U251	SM-31 随机定位器	抑制FAK/RhoA/Rock和FAK / Nek2信号通路
Zhao等^[26]	BL6-10	RPM	通过对Uev1A/TICAM/TRAF/NF-κB调节的细胞凋亡以及p53/PCNA-和ATM/ATR-Chk1/2控制的DNA损伤应答途径的联合调节来促进细胞凋亡应答
Lin等^[27]	NCSCs	RCCS	↑CXCR4表达和RhoA-ROCK1-p38 MAPK-p53信号转导破坏大鼠NCSC的细胞骨架并增加其凋亡
韩标等^[28]	MC3T3-E1	RCCS	激活NF-κB通路来调节MC3T3-E1细胞的分化

参考文献	细胞系	干预条件	结果
Warnke等^[7]	FTC-133	RPM（3 d）	成球时：CAV1、CTGF↓
Riwaldt等^[21]	UCLA RO82-W-1	RPM (24 h)	促进成球（血管生成,防止细胞外蛋白过度积聚）：VEGFA、VEGFD、MSN、MMP3↑;成球时（编码结构蛋白）：ACTB、ACTA2、KRT8、TUBB、EZR、RDX、PRKCA、CAV1、MMP9、PAI1、CTGF、MCP1↓
Kopp等^[22]	FTC-133、Nthy-ori 3-1	RPM（14 d）	重力敏感的生长或血管生成因子参与成球：VEGF、FLT-1、FLK-1、CD44、Copine 1、TGM2、IL-6、IL-8、IL-17、OPN、NGAL、LCN2
Riwaldt等^[29]	FTC-133	太空失重（12 d）	抑制MCS生长的蛋白质：细胞外基质蛋白↑,磷酸化profilin 1↑
Bauer等^[32]	FTC-133	RPM（3 d）	成球时：CAV1、p130cas↓,ASAP1↑, PXN、VCL、PTK2利于成球
Riwaldt等^[33]	FTC-133	太空失重（12 d）	成球时:CAV1、VCAM-1↓, 参与抑制MCS形成：CAV1、VCAM、组织因子、α2巨球蛋白、载脂蛋白B、基质金属蛋白酶1的组织抑制剂和蛋白激酶Cα
Svejgaard等^[34]	ML-1、UCLA RO82-W-1	RPM（7 d）和FRC（7 d）	ML-1细胞：IL-6、MCP-1↑（促进MCS形成）;RO82-W-1细胞（RPM/FRC）：IL-6↑,MCP-1分泌远低于ML-1细胞的释放,MCP-1的释放被抑制
Ma等^[35]	FTC-133	太空失重（10 d）	成球时：（影响血管生成的细胞因子和生长因子的基因表达）IL6、IL15、VEGFD、FGF17↑,VEGFA↓
Pietsch等^[36]	FTC-133	太空失重（10 d）	CTGF, EGF↓
Grosse等^[37]	FTC-133	RPM（24 h）	参与成球：NF-kB

Research on microgravity which affects thyroid tumor

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