Expression of chemokine CXCL5 and programme death ligand 1 in colorectal cancer tissues are associated with prognosis of patients

doi:10.16139/j.1007-9610.2021.06.017

Abstract

Abstract: Objective To analyze the expression of CXCL5 (C-X-C motif ligand 5) and programme death ligand 1 (PD-L1) in colorectal cancer tissues and explore two chemokines associated with clinical characteristics and prognosis. Methods The specimens of tumor tissues and adjacent normal tissues were collected from 78 patients with colorectal cancer who had laparoscopic resection from 2010 to 2011. The clinical data were gotten and follow-up were done for prognosis. Tissue microarrays were made from all specimens and immunohistochemical staining was performed. Expression of CXCL5 and PD-L1 was evaluated using immune risk scoring and analyzed with the association of clinical pathological parameters and prognosis of patients. Results Expression of CXCL5 and PD-L1 was associated with tumor size and TNM stage, and was higher in colorectal cancer tissues than in adjacent normal tissues. Cox univariate regression analysis showed that TNM stage, high expression of both CXCL5 and PD-L1 were the prognostic risk factors for overall survival of colorectal patients. It was shown with multivariate regression analysis that TNM stage and high expression of PD-L1 were the independent prognostic risk factors for overall survival rate. Patients with higher expression of both CXCL5 and PD-L1 had the worst prognosis. Conclusions CXCL5 combined with PD-L1 could stratify the risk of patients with colorectal cancer and predict the prognosis of patients.

Key words: Colorectal cancer, CXCL5, Programmed death ligand 1

CLC Number:

LIU Shiguang, ZHAO Jingkun, LU Aiguo, MAO Zhihai. Expression of chemokine CXCL5 and programme death ligand 1 in colorectal cancer tissues are associated with prognosis of patients[J]. Journal of Surgery Concepts & Practice, 2021, 26(06): 543-549.

Figures/Tables 5

References 25

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临床特征	CXCL5表达		统计学数值	P值	PD-L1表达		统计学数值	P值
临床特征	高	低	统计学数值	P值	高	低	统计学数值	P值
总计	48	30			37	41
性别			1.086	0.297			1.236	0.266
男	23	18			17	24
女	25	12			20	17
年龄（岁）			0.194	0.660			0.360	0.549
<65	28	19			21	26
≥65	20	11			16	15
组织学			3.534	0.171			2.982	0.225
管状	38	28			29	37
黏液	9	2			7	4
乳头状	1	0			1	0
肿瘤直径（cm）			3.945	0.047			4.029	0.045
≥5	27	10			22	15
<5	21	20			15	26
TNM分期			2.735	0.003			11.733	0.008
Ⅰ	5	10			4	10
Ⅱ	21	12			11	16
Ⅲ	16	8			16	15
Ⅳ	6	0			6	0

参数	总生存率
参数	HR	95% CI	P值
单因素分析
年龄（岁）（<65比≥65）	1.003	0.410~2.454	0.995
性别（女比男）	1.812	0.740~4.433	0.193
组织学
乳头状	1.000	..	0.222
管状比乳头状	0.164	0.021~1.272	0.084
黏液比乳头状	0.198	0.020~1.948	0.165
TNM分期
Ⅲ+Ⅳ比Ⅰ+Ⅱ	0.181	0.060~0.541	0.002
肿瘤直径（<5 cm比≥5 cm）	0.537	0.219~1.314	0.173
CXCL5（低表达比高表达）	0.229	0.067~0.783	0.019
PD-L1（低表达比高表达）	0.397	0.164~0.958	0.040
多因素分析
TNM分期
Ⅲ+Ⅳ比Ⅰ+Ⅱ	0.235	0.075~0.734	0.013
CXCL5（低表达比高表达）	0.786	0.202~3.063	0.728
PD-L1（低表达比高表达）	0.156	0.042~0.584	0.006
TNM分期
Ⅲ+Ⅳ比Ⅰ+Ⅱ	0.234	0.076~0.721	0.011
CXCL5（低表达比高表达）	0.345	0.098~1.215	0.098