Study on circulating tumor DNA and circulating tumor cell detecting minimal residual disease in breast cancer

doi:10.16139/j.1007-9610.2022.05.016

Abstract

Abstract:

Breast cancer is the most commonly diagnosed female cancer in the world and 20%-30% patients faced the risk of recurrence and metastasis. Minimal residual disease(MRD) was believed as one of the important factors promo-ting disease progress in breast cancer and was closely associated with poor prognosis. Detection of MRD currently used liquid biopsy including detection of circulating tumor DNA and circulating tumor cell. The methods of detecting MRD in the evaluation of effect and prognosis and recurrence monitoring in breast cancer were explored in this review.

Key words: Minimal residual disease, Breast cancer, Liquid biopsy, Circulating tumor DNA, Circulating tumor cell

CLC Number:

R737.9

PAN Ruixin, CHEN Xiaosong, SHEN Kunwei. Study on circulating tumor DNA and circulating tumor cell detecting minimal residual disease in breast cancer[J]. Journal of Surgery Concepts & Practice, 2022, 27(05): 463-467.

Figures/Tables 1

References 33

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项目	肿瘤知情分析	肿瘤不知情分析
敏感性	高	低
特异性	高	低
体细胞突变的影响	小	大，需通过额外操作降低其影响
适用范围	小，需提供可进行基因检测的原发灶肿瘤组织	大
对获得性突变的检测	仅针对肿瘤原发灶中的突变，难以发现治疗过程中的获得性新发突变	可检测包含在设定panel中的所有突变
费用	高	低
检测所需时间	长，初期需对肿瘤组织检测，后期仅对ctDNA检测	短，初期及后期均仅对ctDNA检测