组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2009, Vol. 5 ›› Issue (4): 205-207.doi: 10.3969/j.issn.1673-0364.2009.08.007

• 论著 • 上一篇    下一篇

局部应用L-精氨酸对糖尿病小鼠创面愈合的影响

陈晓华，于攀，李世荣，王珍祥   

  1. 上海时光整形外科医院;第三军医大学西南医院整形外科;
  • 发布日期:2020-07-23

Effect of L-arginine on the Wound Healing of Diabetic Mice

CHEN Xiaohua1,YU Pan2,LI Shirong2,WANG Zhenxiang2   

  1. 1 Shanghai Time Plastic Surgery Hospital;Shanghai 200021;China;2 Department of Plastic Surgery;Southwest Hospital;Third Military Medical University;Chongqing 400038;China.;
  • Published:2020-07-23

摘要： 目的研究局部应用L-精氨酸对糖尿病小鼠创面治疗效果的影响。方法建立链脲霉素(Streptozotocin,STZ)诱导的Ⅰ型糖尿病小鼠创面模型;昆明小鼠随机分为正常对照组(A组)、糖尿病对照组(B组)、糖尿病精氨酸治疗组(C组),糖尿病小鼠创面模型建立后,观察及测量伤后0、4、8、14、16d时创面愈合面积、肉芽生长情况、组织形态学改变、羟脯氨酸(OHP)含量。结果C组创面愈合明显加快(P<0.05),创面成纤维细胞数量、胶原生成增多,OHP含量增加。结论局部应用L-精氨酸,通过加快肉芽生成,增加创面成纤维细胞数量,能促进糖尿病创面愈合。

关键词: 糖尿病, L-精氨酸, 创面愈合, 一氧化氮

Abstract: Objective To investigate the effect of L-arginine used in the wound of mice with diabetes. Methods Type IDM mice induced by streptozotocin were used as the animal model. Seventy five male KM mice were used in this study and were randomly divided into group A (normal control, n=25), group B (diabetic control, n=25) and group C (diabetes with L- arginine administration, n=25). The percentage of healing areas, the granulation tissue formation, the histological and morphological changes and the content of hydro...

Key words: Diabetes, L-arginine, Wound healing, Nitric Oxide

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