组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2013, Vol. 9 ›› Issue (5): 292-294.doi: 10.3969/j.issn.1673-0364.2013.05.015

• 论著 • 上一篇    下一篇

巨噬细胞参与骨骼肌再生机制的研究进展

乔娟，郝晓艳，郭树忠   

  1. 解放军第309医院；第四军医大学西京医院
  • 发布日期:2020-07-23

Research Progress in Mechanisms of Macrophages Participating in Skeletal Muscle Regeneration

QIAO Juan,HAO Xiaoyan,GUO Shuzhong   

  1. The 9th Hospital of Chinese People’s Liberation Army;Xijing Hospital,Fourth Military Medical University
  • Published:2020-07-23

摘要： 近年来,越来越多的研究证实,巨噬细胞在人体多种组织器官再生过程中发挥重要作用。在骨骼肌再生过程中,巨噬细胞的参与是必需的。骨骼肌受损后,成肌细胞与固有巨噬细胞募集循环系统中的单核/巨噬细胞;浸润的巨噬细胞吞噬凋亡或坏死的肌纤维后,从致炎的表型转变为抗炎表型;抗炎巨噬细胞分泌的因子促进了成肌细胞的分化和融合,从而介导了骨骼肌的再生。

关键词: 巨噬细胞, 骨骼肌再生, 成肌细胞, 巨噬细胞活化, 组织修复

Abstract: In recent years, many researches have demonstrated that macrophages play a vital role in organ or tissue regeneration. Macrophages are necessary for skeletal muscle regeneration after injury. The recruitment of circulating mono-cytes/macrophages was mediated through myogenic cells and muscle resident macrophages. Macrophages are involved in both phases of skeletal muscle regeneration: first, swallowing necrotic myo-fibers, then the phenotype of macrophages switched from pro-inflammatory to anti-inflammatory. Second, factors secreted by anti-inflammatory macrophages improved the differentiation of myogenic cells and resulted in regeneration of skeletal muscle.

Key words: Macrophages, Skeletal muscle regeneration, Myogenic cells, Macrophage activation, Tissue repair

中图分类号: