组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2018, Vol. 14 ›› Issue (4): 219-222.doi: 10.3969/j.issn.1673-0364.2018.04.011

• 综述 • 上一篇    下一篇

脂肪干细胞来源外泌体促进组织修复的应用进展

陈筑昕，综述，周双白，李青峰，审校   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 收稿日期:2018-03-28 修回日期:2018-05-23 发布日期:2020-07-23
  • 作者简介:李青峰（E-mail：dr．liqingfeng@yahoo．com）。

Application of Exosome Derived from Adipose Derived Stem Cells in Promoting Tissue Repair

CHEN Chuhsin,ZHOU Shuangbai,LI Qingfeng   

  1. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine
  • Received:2018-03-28 Revised:2018-05-23 Published:2020-07-23
  • Contact: 国家自然科学基金青年项目(81501678)；国家自然科学基金重点国际合作项目(81620108019)

摘要： 脂肪干细胞具有促进组织修复再生的作用,作用机制与其旁分泌作用密不可分。外泌体是一种细胞分泌的外囊泡结构,是细胞之间通讯的新机制。近年的研究发现,干细胞来源外泌体是干细胞旁分泌活动的一种重要方式,介导其促进组织再生。外泌体的应用为组织修复提供了一种新策略,本文对脂肪干细胞来源外泌体应用于组织修复的研究进展进行综述。

关键词: 脂肪干细胞, 外泌体, 细胞外囊泡, 组织修复

Abstract: Adipose-derived stem cells have the effect of promoting tissue repair and regeneration, and its mechanism of action is inseparable from its paracrine role. Exosomes are extracellular vesicle secreted by cells and are a new mechanism for communication between cells. In recent studies, it has been found that stem cell-derived exosomes are a major means of paracrine activity of stem cells and mediate their role in promoting tissue regeneration. The application of exosomes provides a new strategy for tissue repair. In this paper, the application of exosomes derived from adipose-derived stem cells in tissue regeneration was reviewed.

Key words: Adipose-derived stem cells, Exosome, Extracellular vesicle, Tissue repair

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