组织工程与重建外科杂志 ›› 2014, Vol. 10 ›› Issue (6): 355-362.doi: 10.3969/j.issn.1673-0364.2014.06.015

• 综述 • 上一篇    下一篇

骨形态发生蛋白2/7异源二聚体的研究进展

高涛,周陆陆,苗春雷,唐胜建,刘方军   

  1. 潍坊医学院整形外科医院
  • 发布日期:2020-07-23

Research Progress of Bone Morphogenetic Protein 2/7 Heterodimer

GAO Tao,ZHOU Lulu,MIAO Chunlei,TANG Shengjian,LIU Fangjun   

  1. Plastic Surgery Hospital, Weifang Medical University;
  • Published:2020-07-23
  • Contact: 国家自然科学基金资助项目(81372091)

摘要: 骨形态发生蛋白2/7(BMP2/7)异源二聚体,较其同源二聚体具有更强的诱导成骨潜能,是目前组织工程骨研究的重要分支之一。本文介绍了异源二聚体BMP2/7诱导成骨的相关实验,比较其与同源二聚体生物活性的差异,并对相关机制进行综述。

关键词: 骨形态发生蛋白, 异源二聚体, 骨组织工程, 成骨分化

Abstract: BMP2/7 heterodimer, a bone structure formation protein, has stronger osteogenesis inductive potential than its homodimer. So the study of BMP2/7 heterodimer has been one of the most important research directions in tissue engineering osteogenesis now. In this article, the osteo-inductive related experiments of BMP2/7 heterodimer were described, the differences of biological activity between heterodimer and homodimer were compared, and the mechanisms were overviewed.

Key words: Bone morphogenetic protein, Heterodimer, Bone tissue engineering, Osteogenic differentiation

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