光学透明剂对脉冲染料激光治疗葡萄酒色斑效果的影响

doi:10.3969/j.issn.1673-0364.2020.03.005

摘要/Abstract

摘要：

目的探索外用光学透明剂(Optical clearing agent,OCA)对脉冲染料激光(Pulsed dye laser,PDL)治疗葡萄酒色斑(Port wine stains,PWS)效果的影响。

方法将13例PWS患者的病灶分为两个治疗区域,一为OCA+PDL区,于病灶处外用OCA后行PDL治疗;另一区域为单纯PDL区,不使用OCA直接进行PDL治疗。每位患者均接受3次治疗,每次治疗间隔2个月。治疗结束后3个月以比色法和视觉评估法(Visual Analogue Score,VAS)评价各区疗效。

结果三次治疗后,色度计测量和VAS皆提示OCA+PDL区与单纯PDL区相比疗效无显著差异。但首次治疗后,OCA+PDL区和单纯PDL区的VAS分别为2.69和2.07,差异显著(P=0.025),提示前者在单次治疗后有较显著的色斑改善。所有患者的治疗后副反应均在短期内消退。

结论与单纯PDL相比,外用OCA对PDL的疗效无明显改善。

关键词: 葡萄酒色斑, 脉冲染料激光, 光学透明剂, 甘油

Abstract:

Objective To explore the ef?cacy of optical clearing agent (OCA) on the treatment of port wine stain (PWS) using pulsed dye laser (PDL).

Methods The lesions of 13 patients with PWS were divided into two treatment areas. One of the areas was treated by PDL after applying OCA (OCA+PDL area), the other one was treated by PDL only (PDL area). Each patient underwent three sessions with interval of 2 months. Chromameter and visual evaluation (VAS) were used to evaluate the ef?cacy and side effects of each area three months after the final sessions.

Results After three sessions of treatment, the chromameter and visual evaluation suggested no significant difference between each area. However, after the first session, the VAS of OCA+PDL area and PDL area were 2.69 and 2.07, respectively, showing a significant difference (P=0.025), suggesting that the former had a significant improvement in color spots after one single session. Permanent side effects were not observed in any patient.

Conclusion Compared with single use of PDL, the combined use of OCA does not improve the efficacy of PDL in treating PWS.

Key words: Port wine stain, Pulsed dye laser, Optical clearing agent, Glycerol

中图分类号:

R732.2

陈彦瑀, 于文心, 马刚, 林晓曦. 光学透明剂对脉冲染料激光治疗葡萄酒色斑效果的影响[J]. 组织工程与重建外科杂志, 2020, 16(3): 193-197.

Yanyu CHEN, Wenxin YU, Gang MA, Xiaoxi LIN. The Effect of Optical Clearing Agent on the Treatment of Port-Wine Stains by Pulsed Dye Laser[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2020, 16(3): 193-197.

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No.	Δa		ΔE		Blanching rate
No.	OCA+PDL	PDL	OCA+PDL	PDL	OAC+PDL	PDL
1	-1	-1	4.24	7.35	0.22	0.38
2	2	5	8.49	6.71	0.72	0.43
3	18	22	22.83	25.87	0.63	0.65
4	5	11	5.74	13.08	0.31	0.46
5	2	5	11.36	9.90	0.45	0.73
6	11	12	11.70	13.93	0.61	0.62
7	18	18	19.31	19.31	0.82	0.82
8	0.63	-0.38	3.95	3.60	0.39	0.31
9	5	5	9.11	10.72	0.72	0.72
10	-2.34	0.28	12.35	11.87	0.33	0.39
11	-3.35	-0.65	7.63	6.95	0.24	0.35
12	6.75	11.57	9.48	13.52	0.46	0.49
13	-6.39	-4.47	11.95	9.27	0.42	0.38

No.	第一次治疗后 after the first treatment		第二次治疗后 after the second treatment		第三次治疗后 after the third treatment
No.	OCA+PDL	PDL	OCA+PDL	PDL	OAC+PDL	PDL
1	1	1	2	2	3	3
2	2	2	4	4	5	5
3	2	2	4	4	5	5
4	3	2	3	3	4	4
5	4	4	5	5	5	5
6	4	2	4	3	4	4
7	3	3	4	4	5	5
8	3	1	4	3	4	4
9	3	2	3	2	3	3
10	2	2	2	2	3	3
11	4	2	4	3	4	4
12	2	2	2.5	2.5	3	3
13	2	2	2.5	2.5	3	3