关键词: 动静脉畸形, 动静脉瘘, 动物模型

Abstract: Arteriovenous malformations (AVM) is a relatively rare and high risk vascular malformations. Although endovascular therapy, surgical therapy and combined therapy have been used in clinical practice, there are still many difficulties and challenges in the diagnosis and treatment of this disorder. In recent decades, a variety of experimental models have been developed to study the pathogenesis, hemodynamic changes and histology of AVM, so as to deepen the understanding of the disease and achieve better therapeutic effects. These models have their own advantages and disadvantages, but there is still a lack of animal models that can perfectly simulate various AVM in humans. In this paper, the recent research on AVM related animal models and their advantages and disadvantages in application were all reviewed.

Key words: Arteriovenous malformations, 　Arteriovenous fistula, 　Animal model