组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2011, Vol. 7 ›› Issue (1): 23-26.doi: 10.3969/j.issn.1673-0364.2011.01.006

• 论著 • 上一篇    下一篇

自体骨髓基质干细胞移植治疗糖尿病下肢血管病变

李红普，仝现州，史帅伟   

  1. 郑州人民医院血管外科
  • 发布日期:2020-07-23

The Clinical Application of Autologous Bone Marrow Stem Cells Transplantation in Treating Peripheral Arterial Diseases in Diabetic

LI Hongpu,TONG Xianzhou,SHI Shuaiwei   

  1. Department of Vascular Surgery,Zhengzhou People′s Hospital,Zhengzhou 450003,China.
  • Published:2020-07-23

摘要： 目的探讨自体骨髓基质干细胞(BMSC)移植治疗糖尿病下肢血管病变的可行性和临床效果。方法糖尿病致双下肢血管病变的患者30例(60条下肢),双侧下肢的病变程度接近。以患者自体BMSC对一侧下肢进行治疗,以另一侧下肢为自身对照,对双侧肢体肤色、肢体疼痛、冷感、溃疡、皮温改变、间歇性跛行变化及实验室检查进行比较,观察自体BMSC治疗糖尿病周围血管病变的安全性和有效性。结果治疗侧下肢在肤色、疼痛感、冷感、溃疡、皮温等方面均明显好于对照组,间隙性跛行亦有改善;术后6个月时行数字减影动脉血管造影,治疗组可见丰富的侧支血管形成。结论自体BMSC移植治疗糖尿病下肢血管病变具有可行性,可明显改善症状,效果肯定。

关键词: 骨髓干细胞, 糖尿病, 外周血管病变

Abstract: Objective To evaluate the clinical effects of autologous bone marrow stem cells transplantation in treating diabetic arterial diseases of the lower extremities.Methods Thirty patients with diabetic artery diseases involved in both lower limbs were enrolled in this study.The patients were received autologenous bone marrow stem cell transplantation by intramuscular injections at multiple sites of affected limb.During 15 months of follow-up,symptoms including skin colour,sensation,local ulcers,skin temperature and claudication were observed and compared with the control group.The ankle-bronchial indexes and MRI angiographic results were recorded.Results The symptoms were greatly relieved and the walking distance without pain was dramatically prolonged.The ankle-bronchial indexes were increased from 0.35±0.20 to 0.56±0.10(P<0.05) after cellular treatment.Conclusion Autologous bone marrow stem cells transplantation is safe,effective and feasible for the treatment of peripheral arterial vascular disease in diabetic.

Key words: Bone marrow stem cells, Diabetes, Peripheral vascular disease.

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