Journal of Tissue Engineering and Reconstructive Surgery ›› 2009, Vol. 5 ›› Issue (4): 195-198.doi: 10.3969/j.issn.1673-0364.2009.08.004

• Original article • Previous Articles     Next Articles

Effects of AcSDKP on TGF-β1 Expression in Human Dermal Fibroblasts

DENG Zhiming,ZHAO Xibin,ZHENGJianghong,DENG Chenliang,DING Zhi,MAO Guangyu,WANG Huidong,YANG Songlin   

  1. Shanghai Sixth People′s Hospital;Shanghai Jiaotong University School of Medicine;Shanghai 200233;China.;
  • Published:2020-07-23
  • Contact: 国家自然科学基金(30571929) 上海市卫生局资助课题(2006055)

Abstract: Objective To study the effects of N-acetyl-seryl-aspartyl-lysyl-praline (AcSDKP) on TGF-β1 synthesis in human dermal fibroblasts. Methods Human dermal fibroblast after Primary cultures and identification were subjected to AcSDKP (10-7 mol/L, 10-8 mol/L, 10-9 mol/L, 10-10 mol/L, 10-11 mol/L, respectively) treatment. The control group was not seeded AcSDKP. The proliferation of human dermal fibroblasts were detected by WST-8. The expression of TGF-β1 mRNA were analyzed with RT-PCR. TGF-β1 in the supernatant w...

Key words: AcSDKP, Dermal fibroblast, TGF-β1, Expression

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