Abstract: Objective To determine the efficacy of Botulinum toxin type A （BTA） for the treatment of hyperkinetic lines of the face. Methods A total of 78 patients who received BTA injection to remove facial wrinkles from December 2012 to June 2013 were enrolled. All of 78 patients were females and the age of the patients ranged from 27 to 46 years. The treatment was done in two different sessions and divided into 2 treatment subgroups of forehead （48）, crow＇s feet （30）. The short-term efficacy of BTA was analyzed at the injection day and 1 month, 3 months, 6 months and 9 months after injection. Efficacy was evaluated by contrast of photo difference, measuring changes of facial wrinkles and patient self-evaluation between pre-operation and post- operation. Results All the patients were followed up for a period of 9 months and graded for the response to treatment with BTA by the operator, observer and the patient independently using the facial wrinkle scale （FWS）. These cases who received BTA injection had significant improvement in the skin around the eye status and forehead,The results of applying BTA for the treatment of hyperkinetic lines of the face were satisfactory. Conclusion BTA is characterized with a high successful rate and rare complication. It is an ideal method for the treatment of hyperkinetic lines of the face.

Key words: Botulinum Toxin A, Injection Treatment, Hyperkinetic lines, Face