Abstract: Objective To explore the effects of Salvia mihiorrhiza and Astragalus propinquus injection on the survival of transplanted grafts, so as to provide evidence for further research and clinical application. Methods Autologous adipose tissue transplantation model was established using New Zealand white rabbit. The experimental groups were given S. miltiorrhiza and A. propinquus injection intraperitoneally. The expression levels of VEGF in serum and survival rates were measured and calculated at different time points. Tissue morphology was observed by HE staining. The expression of platelet endothelial cell adhesion molecule-1 （CD31） and perilipin were observed by immune-histochemistry to evaluate the neocapillary growth and cyto-activity of transplanted adipose tissue. Results Twelve weeks after transplantation, the survival rates in experimental groups were higher than the control group. The expression levels of VEGF in serum in experimental groups were significantly higher than those in the control group at each time point. HE and immuno-histochemical staining demonstrated better morphology, denser neo-capillaries and higher cyto-activity in experimental groups, compared with the control group. Conclusion By applying S. mihiorrhiza and A. propinquus injection, the survival of autologous transplanted adipose tissue can be significantly enhanced in New Zealand rabbits.

Key words: Salvia miltiorrhiza injection, Astragalus propinquus injection, Autologous adipose tissue transplantation, Survival rate